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Synthesis and Evaluation of Stearylated Hyaluronic Acid for the Active Delivery of Liposomes to Liver Endothelial Cells

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タイトル: Synthesis and Evaluation of Stearylated Hyaluronic Acid for the Active Delivery of Liposomes to Liver Endothelial Cells
著者: Toriyabe, Naoyuki 著作を一覧する
Hayashi, Yasuhiro 著作を一覧する
Hyodo, Mamoru 著作を一覧する
Harashima, Hideyoshi 著作を一覧する
キーワード: hyaluronic acid
liver endothelial cell
active targeting
liposome
発行日: 2011年 7月
出版者: Pharmaceutical Society of Japan
誌名: Biological & Pharmaceutical Bulletin
巻: 34
号: 7
開始ページ: 1084
終了ページ: 1089
出版社 DOI: 10.1248/bpb.34.1084
抄録: Hyaluronic acid (HA) is a naturally-occurring ligand that can be useful for targeting liver endothelial cells. We describe herein the development of a new HA-lipid conjugate for the efficient delivery of liposomes to liver endothelial cells. When free HA coated cationic liposomes were injected into mice, their accumulation in the liver was significantly decreased depending on the content of free HA, while accumulation in the lung was not significantly changed. When cationic liposomes modified with HA-stearylamine (HA-SA conjugate) were injected in mice, liver accumulation was increased depending on the amount of HA-SA conjugate and accumulation in the lung was drastically reduced, compared to non-modified liposomes. Confocal imaging analyses showed that HA-SA modified liposomes were accumulated to a greater extent along with blood vessels than non-modified liposomes, suggesitng that HA-SA modified liposomes are distributed in endothelial cells in the liver. Collectively, these findings indicate that an HA-SA conjugate is a useful material that can be used to modify liposomes and for delivering bioactive liposomal cargoes to liver endothelial cells.
資料タイプ: article
URI: http://hdl.handle.net/2115/46829
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 林 泰弘

 

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