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Intramolecular hydroamination of alkynic sulfonamides catalyzed by a gold-triethynylphosphine complex : Construction of azepine frameworks by 7-exo-dig cyclization
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| Title: | Intramolecular hydroamination of alkynic sulfonamides catalyzed by a gold-triethynylphosphine complex : Construction of azepine frameworks by 7-exo-dig cyclization |
| Authors: | Ito, Hideto Browse this author | | Harada, Tomoya Browse this author | | Ohmiya, Hirohisa Browse this author | | Sawamura, Masaya Browse this author |
| Keywords: | azepine | | cyclization | | gold catalyst | | hydroamination | | triethynylphosphine |
| Issue Date: | 8-Jul-2011 |
| Publisher: | Beilstein-Institut |
| Journal Title: | Beilstein Journal of Organic Chemistry |
| Volume: | 7 |
| Start Page: | 951 |
| End Page: | 959 |
| Publisher DOI: | 10.3762/bjoc.7.106 |
| Abstract: | The gold-catalyzed, seven-membered ring forming, intramolecular hydroamination of alkynic sulfonamides has been investigated. The protocol, with a semihollow-shaped triethynylphosphine as a ligand for gold, allowed the synthesis of a variety of azepine derivatives, which are difficult to access by other methods. Both alkynic sulfoamides with a flexible linear chain and the benzene-fused substrates underwent 7-exo-dig cyclization to afford the nitrogen-containing heterocyclic seven-membered rings, such as tetrahydroazepine and dihydrobenzazepine, in good yields. |
| Rights: | http://creativecommons.org/licenses/by/2.0 |
| Type: | article |
| URI: | http://hdl.handle.net/2115/46884 |
| Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 澤村 正也
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