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2-(p-Nitrophenyl)-2′-deoxyadenosine, a new type of mutagenic nucleoside
| Title: | 2-(p-Nitrophenyl)-2′-deoxyadenosine, a new type of mutagenic nucleoside |
| Authors: | Matsuda, Akira Browse this author | | Ohara, Yoshiko Browse this author | | Kakutani, Toshifumi Browse this author | | Negishi, Kazuo Browse this author | | Wataya, Yusuke Browse this author | | Hayatsu, Hikoya Browse this author | | Ueda, Tohru Browse this author |
| Issue Date: | Apr-1990 |
| Publisher: | Oxford University Press |
| Journal Title: | Nucleic Acids Research |
| Volume: | 18 |
| Issue: | 7 |
| Start Page: | 1833 |
| End Page: | 1838 |
| Publisher DOI: | 10.1093/nar/18.7.1833 |
| Abstract: | A crude preparation of 2-phenyladenosine was found to be mutagenlc in the Ames Salmonella assay. In the purification of this preparation, it was revealed that 2-phenyladenosine itself was nonmutagenic but that 2-(m- and p-nitrophenyl)-adenosines (5m,p) contaminating the sample were the mutagenic principles. A structure-activity relationship study was carried out, and it was found that 5p, 2-(p-nitrophenyl)- adenine (7p), and 2-(p-nitrophenyl)-2′-deoxyadenosine (15p) were strongly mutagenic toward S. typhimurium TA98 and TA100 without metabolic activation, the potency being in the order 15p > 7p > 5p. The potency of 15p in TA98 was one order of magnitude greater than that of 4-nitroquinoline N-oxide. 15p also showed mutagenicity in the mouse cell line FM3A in culture. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/46969 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 彰
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