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2-(p-Nitrophenyl)-2′-deoxyadenosine, a new type of mutagenic nucleoside

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Title: 2-(p-Nitrophenyl)-2′-deoxyadenosine, a new type of mutagenic nucleoside
Authors: Matsuda, Akira Browse this author
Ohara, Yoshiko Browse this author
Kakutani, Toshifumi Browse this author
Negishi, Kazuo Browse this author
Wataya, Yusuke Browse this author
Hayatsu, Hikoya Browse this author
Ueda, Tohru Browse this author
Issue Date: Apr-1990
Publisher: Oxford University Press
Journal Title: Nucleic Acids Research
Volume: 18
Issue: 7
Start Page: 1833
End Page: 1838
Publisher DOI: 10.1093/nar/18.7.1833
Abstract: A crude preparation of 2-phenyladenosine was found to be mutagenlc in the Ames Salmonella assay. In the purification of this preparation, it was revealed that 2-phenyladenosine itself was nonmutagenic but that 2-(m- and p-nitrophenyl)-adenosines (5m,p) contaminating the sample were the mutagenic principles. A structure-activity relationship study was carried out, and it was found that 5p, 2-(p-nitrophenyl)- adenine (7p), and 2-(p-nitrophenyl)-2′-deoxyadenosine (15p) were strongly mutagenic toward S. typhimurium TA98 and TA100 without metabolic activation, the potency being in the order 15p > 7p > 5p. The potency of 15p in TA98 was one order of magnitude greater than that of 4-nitroquinoline N-oxide. 15p also showed mutagenicity in the mouse cell line FM3A in culture.
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 彰

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