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Insights into the Structures of DNA Damaged by Hydroxyl Radical: Crystal Structures of DNA Duplexes Containing 5-Formyluracil
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| Title: | Insights into the Structures of DNA Damaged by Hydroxyl Radical: Crystal Structures of DNA Duplexes Containing 5-Formyluracil |
| Authors: | Tsunoda, Masaru Browse this author | | Sakaue, Takeshi Browse this author | | Naito, Satoko Browse this author | | Sunami, Tomoko Browse this author | | Abe, Naoko Browse this author | | Ueno, Yoshihito Browse this author | | Matsuda, Akira Browse this author | | Takénaka, Akio Browse this author |
| Issue Date: | 2010 |
| Publisher: | Hindawi Publishing |
| Journal Title: | Journal of Nucleic Acids |
| Volume: | 2010 |
| Start Page: | 1 |
| End Page: | 10 |
| Publisher DOI: | 10.4061/2010/107289 |
| Abstract: | Hydroxyl radicals are potent mutagens that attack DNA to form various base and ribose derivatives. One of the major damaged thymine derivatives is 5-formyluracil (fU), which induces pyrimidine transition during replication. In order to establish the structural basis for such mutagenesis, the crystal structures of two kinds of DNA d(CGCGRATfUCGCG) with R = A/G have been determined by X-ray crystallography. The fU residues form a Watson-Crick-type pair with A and two types of pairs (wobble and reversed wobble) with G, the latter being a new type of base pair between ionized thymine base and guanine base. In silico structural modeling suggests that the DNA polymerase can accept the reversed wobble pair with G, as well as the Watson-Crick pair with A. |
| Rights: | http://creativecommons.org/licenses/by-nc-sa/2.1/jp/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/46984 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 彰
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