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Novel Synthesis of Optically Active Bishomotyrosine Derivatives Using the Friedel-Crafts Reaction in Triflic Acid

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Title: Novel Synthesis of Optically Active Bishomotyrosine Derivatives Using the Friedel-Crafts Reaction in Triflic Acid
Authors: Murai, Yuta Browse this author
Hashidoko, Yasuyuki Browse this author
Hashimoto, Makoto Browse this author
Keywords: bishomotyrosine
phenol
Friedel-Crafts reaction
Fries rearrangement
triflic acid
Issue Date: 2011
Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry
Journal Title: Bioscience, Biotechnology, and Biochemistry
Volume: 75
Issue: 2
Start Page: 352
End Page: 354
Publisher DOI: 10.1271/bbb.100595
Abstract: We report here a novel synthesis of optically active bishomotyrosine. The bishomotyrosine skeleton was constructed by using a Friedel-Crafts reaction between phenol and optically active N-Tfa-Glu(Cl)-OMe in triflic acid under the mild condition. Reduction and subsequent deprotection then afforded bishomotyrosine derivatives without any loss of optical purity.
Type: article
URI: http://hdl.handle.net/2115/47098
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 橋本 誠

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