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Effects of γ-hexachlorocyclohexane on apoptosis induced by serum deprivation in PC12 cells

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/47396

Title: Effects of γ-hexachlorocyclohexane on apoptosis induced by serum deprivation in PC12 cells
Authors: Aoki, Kentaro Browse this author
Egawa, Mari Browse this author
Saito, Takeshi Browse this author
Hosokawa, Toshiyuki Browse this author
Kurasaki, Masaaki Browse this author
Keywords: Apoptosis
γ-HCH
PC12 cell
caspase
cytochrome C
Bcl-2 family
Issue Date: Aug-2008
Publisher: Taylor & Francis
Journal Title: Journal of Environmental Science and Health, Part B : Pesticides, Food Contaminants, & Agricultural Wastes
Volume: 43
Issue: 6
Start Page: 471
End Page: 475
Publisher DOI: 10.1080/03601230802174573
PMID: 18665982
Abstract: The effects of γ-hexachlorocyclohexane, one of the endocrine disrupters, widely used for agricultural and medicinal purpose, on apoptosis in PC12 cells were investigated using western blotting analysis and reverse transcriptase-DNA polymerase chain reaction (RT-PCR) method. Apoptosis is a fundamental process necessary for development of individuals and organs. Although γ -HCH at high concentration did not have an effect on cell viability and apoptosis, DNA fragmentation was slightly enhanced, and apoptotic factors; Bax, Bad, cytochrome c and caspase-3 showed tendency to increase by the addition of a low dose of γ-HCH to the cell medium. However these changes were not statistically significant. It was concluded that γ -HCH did not affect on apoptosis in the PC12 cell line system, although γ -HCH has been reported to induce apoptosis in other cell lines.
Rights: This is a preprint of an article submitted for consideration in the Journal of Environmental Science and Health, Part B © 2008 Taylor & Francis. Journal of Environmental Science and Health, Part B is available online at: www.tandfonline.com.
Relation: http://www.tandfonline.com/openurl?genre=article&issn=03601234&volume=43&issue=6&spage=471
Type: article (author version)
URI: http://hdl.handle.net/2115/47396
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藏崎 正明

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