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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Environmental Science / Faculty of Environmental Earth Science >
Peer-reviewed Journal Articles, etc >
Effects of γ-hexachlorocyclohexane on apoptosis induced by serum deprivation in PC12 cells
| Title: | Effects of γ-hexachlorocyclohexane on apoptosis induced by serum deprivation in PC12 cells |
| Authors: | Aoki, Kentaro Browse this author | | Egawa, Mari Browse this author | | Saito, Takeshi Browse this author | | Hosokawa, Toshiyuki Browse this author | | Kurasaki, Masaaki Browse this author |
| Keywords: | Apoptosis | | γ-HCH | | PC12 cell | | caspase | | cytochrome C | | Bcl-2 family |
| Issue Date: | Aug-2008 |
| Publisher: | Taylor & Francis |
| Journal Title: | Journal of Environmental Science and Health, Part B : Pesticides, Food Contaminants, & Agricultural Wastes |
| Volume: | 43 |
| Issue: | 6 |
| Start Page: | 471 |
| End Page: | 475 |
| Publisher DOI: | 10.1080/03601230802174573 |
| PMID: | 18665982 |
| Abstract: | The effects of γ-hexachlorocyclohexane, one of the endocrine disrupters, widely used for agricultural and medicinal purpose, on apoptosis in PC12 cells were investigated using western blotting analysis and reverse transcriptase-DNA polymerase chain reaction (RT-PCR) method. Apoptosis is a fundamental process necessary for development of individuals and organs. Although γ -HCH at high concentration did not have an effect on cell viability and apoptosis, DNA fragmentation was slightly enhanced, and apoptotic factors; Bax, Bad, cytochrome c and caspase-3 showed tendency to increase by the addition of a low dose of γ-HCH to the cell medium. However these changes were not statistically significant. It was concluded that γ -HCH did not affect on apoptosis in the PC12 cell line system, although γ -HCH has been reported to induce apoptosis in other cell lines. |
| Rights: | This is a preprint of an article submitted for consideration in the Journal of Environmental Science and Health, Part B © 2008 Taylor & Francis. Journal of Environmental Science and Health, Part B is available online at: www.tandfonline.com. |
| Relation: | http://www.tandfonline.com/openurl?genre=article&issn=03601234&volume=43&issue=6&spage=471 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/47396 |
| Appears in Collections: | 環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 藏崎 正明
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