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Cell penetrating peptide-mediated systemic siRNA delivery to the liver

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Title: Cell penetrating peptide-mediated systemic siRNA delivery to the liver
Authors: Hayashi, Yasuhiro Browse this author →KAKEN DB
Yamauchi, Jun Browse this author
Khalil, Ikramy A. Browse this author
Kajimoto, Kazuaki Browse this author
Akita, Hidetaka Browse this author
Harashima, Hideyoshi Browse this author
Keywords: Cell penetrating peptide
Octaarginine
siRNA delivery
Liver
Issue Date: 31-Oct-2011
Publisher: Elsevier B.V.
Journal Title: International Journal of Pharmaceutics
Volume: 419
Issue: 1-2
Start Page: 308
End Page: 313
Publisher DOI: 10.1016/j.ijpharm.2011.07.038
PMID: 21827843
Abstract: The cell-penetrating peptide (CPP) is one of the most attractive tools for efficiently delivering biomolecules to a target organelle. Here, we describe the use of octaarginine (R8)-modified lipid nanoparticles for the efficient and targeted in vivo delivery of siRNA to the liver. In this study, SR-BI (a scavenger receptor class B, member 1) was targeted by this nanoparticle. Our results demonstrate that R8-modified lipid nanoparticles can be used for the efficient and targeted delivery of liver siRNA to induce the specific knock-down of an endogenous gene with minimum liver toxicity and immune response, and that this CPP based technology holds considerable promise for further in vivo biological applications of siRNA.
Type: article (author version)
URI: http://hdl.handle.net/2115/47472
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 林 泰弘

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