Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >
Cell penetrating peptide-mediated systemic siRNA delivery to the liver
Title: | Cell penetrating peptide-mediated systemic siRNA delivery to the liver |
Authors: | Hayashi, Yasuhiro Browse this author →KAKEN DB | Yamauchi, Jun Browse this author | Khalil, Ikramy A. Browse this author | Kajimoto, Kazuaki Browse this author | Akita, Hidetaka Browse this author | Harashima, Hideyoshi Browse this author |
Keywords: | Cell penetrating peptide | Octaarginine | siRNA delivery | Liver |
Issue Date: | 31-Oct-2011 |
Publisher: | Elsevier B.V. |
Journal Title: | International Journal of Pharmaceutics |
Volume: | 419 |
Issue: | 1-2 |
Start Page: | 308 |
End Page: | 313 |
Publisher DOI: | 10.1016/j.ijpharm.2011.07.038 |
PMID: | 21827843 |
Abstract: | The cell-penetrating peptide (CPP) is one of the most attractive tools for efficiently delivering biomolecules to a target organelle. Here, we describe the use of octaarginine (R8)-modified lipid nanoparticles for the efficient and targeted in vivo delivery of siRNA to the liver. In this study, SR-BI (a scavenger receptor class B, member 1) was targeted by this nanoparticle. Our results demonstrate that R8-modified lipid nanoparticles can be used for the efficient and targeted delivery of liver siRNA to induce the specific knock-down of an endogenous gene with minimum liver toxicity and immune response, and that this CPP based technology holds considerable promise for further in vivo biological applications of siRNA. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/47472 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 林 泰弘
|