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Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering

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Title: Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering
Authors: Trirongjitmoah, Suchin Browse this author
Sakurai, Toshihiro Browse this author
Iinaga, Kazuya Browse this author
Chiba, Hitoshi Browse this author
Shimizu, Koichi Browse this author →KAKEN DB
Issue Date: 15-Mar-2010
Publisher: Optical Society of America
Journal Title: Optics Express
Volume: 18
Issue: 6
Start Page: 6315
End Page: 6326
Publisher DOI: 10.1364/OE.18.006315
PMID: 20389654
Abstract: Small, dense low-density lipoprotein (sdLDL) in total LDL is strongly related with the cardiovascular risk level. An optical technique using dynamic light scattering (DLS) measurement is useful for point-of-care testing of sdLDL. However, the sdLDL fraction estimated from the particle size distribution in DLS data is sensitive to noise and artifacts. Therefore, we derived analytical solutions in a closed form to estimate the fraction of scatterers using the autocorrelation function of scattered light from a polydisperse solution. The effect of the undesired large particles can be eliminated by the pre-processing of the autocorrelation function. The proposed technique was verified using latex standard particles and LDL solutions. Results suggest the feasibility of this technique to estimate the sdLDL fraction using optical scattering measurements.
Rights: ©2010 Optical Society of America
Type: article
URI: http://hdl.handle.net/2115/47804
Appears in Collections:情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 清水 孝一

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