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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Information Science and Technology / Faculty of Information Science and Technology >
Peer-reviewed Journal Articles, etc >
Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering
| Title: | Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering |
| Authors: | Trirongjitmoah, Suchin Browse this author | | Sakurai, Toshihiro Browse this author | | Iinaga, Kazuya Browse this author | | Chiba, Hitoshi Browse this author | | Shimizu, Koichi Browse this author →KAKEN DB |
| Issue Date: | 15-Mar-2010 |
| Publisher: | Optical Society of America |
| Journal Title: | Optics Express |
| Volume: | 18 |
| Issue: | 6 |
| Start Page: | 6315 |
| End Page: | 6326 |
| Publisher DOI: | 10.1364/OE.18.006315 |
| PMID: | 20389654 |
| Abstract: | Small, dense low-density lipoprotein (sdLDL) in total LDL is strongly related with the cardiovascular risk level. An optical technique using dynamic light scattering (DLS) measurement is useful for point-of-care testing of sdLDL. However, the sdLDL fraction estimated from the particle size distribution in DLS data is sensitive to noise and artifacts. Therefore, we derived analytical solutions in a closed form to estimate the fraction of scatterers using the autocorrelation function of scattered light from a polydisperse solution. The effect of the undesired large particles can be eliminated by the pre-processing of the autocorrelation function. The proposed technique was verified using latex standard particles and LDL solutions. Results suggest the feasibility of this technique to estimate the sdLDL fraction using optical scattering measurements. |
| Rights: | ©2010 Optical Society of America |
| Type: | article |
| URI: | http://hdl.handle.net/2115/47804 |
| Appears in Collections: | 情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 清水 孝一
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