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Formation of motile assembly of microtubules driven by kinesins

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Title: Formation of motile assembly of microtubules driven by kinesins
Authors: Kawamura, Ryuzo Browse this author
Kakugo, Akira Browse this author →KAKEN DB
Shikinaka, Kazuhiro Browse this author
Osada, Yoshihito Browse this author →KAKEN DB
Gong, Jian Ping Browse this author →KAKEN DB
Issue Date: Dec-2011
Publisher: IOP Publishing
Journal Title: Smart Materials and Structures
Volume: 20
Issue: 12
Start Page: 124007
Publisher DOI: 10.1088/0964-1726/20/12/124007
Abstract: Microtubule (MT) and kinesin are rail and motor proteins that are involved in various moving events of eukaryotic cells in natural systems. In vitro, the sliding motion of microtubules (rail) can be reproduced on a kinesin (motor protein)-coated surface coupled with adenosine triphosphate (ATP) hydrolysis, which is called a "motility assay". Based on this technique, a method was recently established to form MT assemblies by an active self-organization (AcSA) process, in which MTs are crosslinked during a sliding motion on a kinesin-coated surface. Streptavidin (ST) was employed as glue to crosslink biotin-labeled MTs. Various shapes, sizes, and motilities were formed with the AcSA MT assemblies, depending on the initial conditions. In this paper, we briefly review our recent work on the formation of MT assemblies on a kinesin-coated surface.
Rights: This is an author-created, un-copyedited version of an article accepted for publication in Smart Materials and Structures. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at 10.1088/0964-1726/20/12/124007.
Type: article (author version)
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 龔 剣萍 (Gong Jian Ping)

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