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High expression of MeCP2 in JC virus-infected cells of progressive multifocal leukoencephalopathy brains

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Title: High expression of MeCP2 in JC virus-infected cells of progressive multifocal leukoencephalopathy brains
Authors: Shirai, Saya Browse this author
Takahashi, Kenta Browse this author
Kohsaka, Shinji Browse this author
Tsukamoto, Tetsu Browse this author
Isogai, Hiroshi Browse this author
Kudo, Shinichi Browse this author
Sawa, Hirofumi Browse this author
Nagashima, Kazuo Browse this author
Tanaka, Shinya Browse this author →KAKEN DB
Keywords: MeCP2
JC virus infection
large T antigen
Issue Date: Feb-2011
Publisher: Blackwell Publishing
Journal Title: Neuropathology
Volume: 31
Issue: 1
Start Page: 38
End Page: 41
Publisher DOI: 10.1111/j.1440-1789.2010.01122.x
PMID: 20497345
Abstract: Mutations of the methyl CpG binding protein 2 (MeCP2) gene are a major cause of Rett syndrome. To investigate whether the expression of this gene was related to JC virus (JCV) infection, we examined brains of four progressive multifocal leukoencephalopathy (PML) patients. JCV infection was confirmed by immunohistochemical labeling with antibodies against JCV VP1, Agnoprotein and large T antigen. MeCP2 expression was examined by immunohistochemistry using a specific polyclonal antibody against MeCP2. In normal brains and uninfected cortices of PML brains, MeCP2 expression was observed in the nuclei of neurons, but not observed in glial and endothelial cell nuclei. In PML brains, however, intense immunolabeling was observed in abnormally enlarged glial nuclei of JCV-infected cells. Double immunolabeling using antibodies against large T antigen (visualized as blue) and MeCP2 (visualised as red) revealed purple JCV infected nuclei, which confirmed that the JCV infected nuclei expressed MeCP2. We conclude that MeCP2 is highly expressed in the JCV infected nuclei of PML brain and these results may provide a new insight into the mechanism which regulates the MeCP2 expression in glial cells by the infection of JCV.
Rights: The definitive version is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田中 伸哉

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