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High expression of MeCP2 in JC virus-infected cells of progressive multifocal leukoencephalopathy brains

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タイトル: High expression of MeCP2 in JC virus-infected cells of progressive multifocal leukoencephalopathy brains
著者: Shirai, Saya 著作を一覧する
Takahashi, Kenta 著作を一覧する
Kohsaka, Shinji 著作を一覧する
Tsukamoto, Tetsu 著作を一覧する
Isogai, Hiroshi 著作を一覧する
Kudo, Shinichi 著作を一覧する
Sawa, Hirofumi 著作を一覧する
Nagashima, Kazuo 著作を一覧する
Tanaka, Shinya 著作を一覧する
キーワード: MeCP2
PML
JC virus infection
large T antigen
immunohistochemistry
発行日: 2011年 2月
出版者: Blackwell Publishing
誌名: Neuropathology
巻: 31
号: 1
開始ページ: 38
終了ページ: 41
出版社 DOI: 10.1111/j.1440-1789.2010.01122.x
抄録: Mutations of the methyl CpG binding protein 2 (MeCP2) gene are a major cause of Rett syndrome. To investigate whether the expression of this gene was related to JC virus (JCV) infection, we examined brains of four progressive multifocal leukoencephalopathy (PML) patients. JCV infection was confirmed by immunohistochemical labeling with antibodies against JCV VP1, Agnoprotein and large T antigen. MeCP2 expression was examined by immunohistochemistry using a specific polyclonal antibody against MeCP2. In normal brains and uninfected cortices of PML brains, MeCP2 expression was observed in the nuclei of neurons, but not observed in glial and endothelial cell nuclei. In PML brains, however, intense immunolabeling was observed in abnormally enlarged glial nuclei of JCV-infected cells. Double immunolabeling using antibodies against large T antigen (visualized as blue) and MeCP2 (visualised as red) revealed purple JCV infected nuclei, which confirmed that the JCV infected nuclei expressed MeCP2. We conclude that MeCP2 is highly expressed in the JCV infected nuclei of PML brain and these results may provide a new insight into the mechanism which regulates the MeCP2 expression in glial cells by the infection of JCV.
Rights: The definitive version is available at wileyonlinelibrary.com
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/48164
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 田中 伸哉

 

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