|
Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >
Expression of Sorting Nexin 18 (SNX18) Is Dynamically Regulated in Developing Spinal Motor Neurons
| Title: | Expression of Sorting Nexin 18 (SNX18) Is Dynamically Regulated in Developing Spinal Motor Neurons |
| Authors: | Nakazawa, Shiori Browse this author | | Gotoh, Naoya Browse this author | | Matsumoto, Hirotaka Browse this author | | Murayama, Chiaki Browse this author | | Suzuki, Toshiharu Browse this author | | Yamamoto, Tohru Browse this author |
| Keywords: | sorting nexin | | SNX18 | | SNX9-family | | motor neuron | | DRG neuron | | growth cone |
| Issue Date: | Feb-2011 |
| Publisher: | Sage Publications |
| Journal Title: | Journal of Histochemistry & Cytochemistry |
| Volume: | 59 |
| Issue: | 2 |
| Start Page: | 202 |
| End Page: | 213 |
| Publisher DOI: | 10.1369/0022155410392231 |
| Abstract: | The sorting nexin (SNX) family proteins, which contain a Phox homology (PX) domain, play crucial roles in regulating the intracellular membrane trafficking of the endocytic pathway. The proper coordination of this pathway is important for axonal elongation; however, little is known about the expression and intracellular dynamics of the SNX members during the formation of the nervous system. Here we found that SNX18, which belongs to the Src-homology-3-PX-Bin/Amphiphysin/Rvs domain-containing SNX subfamily, was specifically expressed in differentiating motor neurons in the chick and mouse embryonic spinal cord. The expression of SNX18 in embryonic spinal motor neurons was transient and was down-regulated as the neurons matured. We further demonstrated that the localization of EGFP-SNX18 in growth cones was dynamically regulated and accumulated especially at areas in contact with permissive substrates. Our findings collectively suggest that SNX18 may play an active role in axonal elongation. |
| Rights: | The final, definitive version of this article has been published in the Journal, Journal of Histochemistry & Cytochemistry, 59(2), 2011 of publication, © The Author(s) 2011 by SAGE Publications Ltd at the Journal of Histochemistry & Cytochemistry page: http://jhc.sagepub.com/ on SAGE Journals Online: http://online.sagepub.com/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/48172 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 山本 融
|
