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Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases

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Title: Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases
Authors: Kamiya, Hiroyuki Browse this author →KAKEN DB
Keywords: oxidized DNA precursor
8-Hydroxy-dGTP
2-Hydroxy-dATP
Translesion synthesis DNA polymerase
Nucleotide pool sanitization enzyme
DNA repair enzyme
Issue Date: 28-Nov-2010
Publisher: Elsevier B.V.
Journal Title: Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume: 703
Issue: 1
Start Page: 32
End Page: 36
Publisher DOI: 10.1016/j.mrgentox.2010.06.003
PMID: 20542139
Abstract: The base moieties of DNA precursors in the nucleotide pool are subjected to oxidative damage, and the formation of damaged DNA precursors is an important source of mutagenesis. 8-Hydroxy-2'-deoxyguanosine 5'-triphosphate, also known by the name of its keto-enol tautomer as 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate, and 2-hydroxy-2'-deoxyadenosine 5'-triphosphate have been identified as the major products of in vitro oxidation reactions. The mutagenicities of these damaged precursors in living cells will be summarized in this review. In addition, the roles of the nucleotide pool sanitization and DNA repair enzymes, and the translesion synthesis DNA polymerases will be described.
Type: article (author version)
URI: http://hdl.handle.net/2115/48353
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 紙谷 浩之

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