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Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases
| Title: | Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases |
| Authors: | Kamiya, Hiroyuki Browse this author →KAKEN DB |
| Keywords: | oxidized DNA precursor | | 8-Hydroxy-dGTP | | 2-Hydroxy-dATP | | Translesion synthesis DNA polymerase | | Nucleotide pool sanitization enzyme | | DNA repair enzyme |
| Issue Date: | 28-Nov-2010 |
| Publisher: | Elsevier B.V. |
| Journal Title: | Mutation Research/Genetic Toxicology and Environmental Mutagenesis |
| Volume: | 703 |
| Issue: | 1 |
| Start Page: | 32 |
| End Page: | 36 |
| Publisher DOI: | 10.1016/j.mrgentox.2010.06.003 |
| PMID: | 20542139 |
| Abstract: | The base moieties of DNA precursors in the nucleotide pool are subjected to oxidative damage, and the formation of damaged DNA precursors is an important source of mutagenesis. 8-Hydroxy-2'-deoxyguanosine 5'-triphosphate, also known by the name of its keto-enol tautomer as 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate, and 2-hydroxy-2'-deoxyadenosine 5'-triphosphate have been identified as the major products of in vitro oxidation reactions. The mutagenicities of these damaged precursors in living cells will be summarized in this review. In addition, the roles of the nucleotide pool sanitization and DNA repair enzymes, and the translesion synthesis DNA polymerases will be described. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/48353 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 紙谷 浩之
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