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Atg14, a key player in orchestrating autophagy

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/48556

Title: Atg14, a key player in orchestrating autophagy
Authors: Obara, Keisuke Browse this author →KAKEN DB
Ohsumi, Yoshinori Browse this author →KAKEN DB
Issue Date: 2011
Publisher: Hindawi Publishing
Journal Title: International Journal of Cell Biology
Volume: 2011
Publisher DOI: 10.1155/2011/713435
Abstract: Phosphorylation of phosphatidylinositol (PtdIns) by a PtdIns 3-kinase is an essential process in autophagy. Atg14, a specific subunit of one of the PtdIns 3-kinase complexes, targets the complex to the probable site of autophagosome formation, thereby, sorting the complex to function specifically in autophagy. The N-terminal half of Atg14, containing coiled-coil domains, is required to form the PtdIns 3-kinase complex and target it to the proper site. The C-terminal half of yeast Atg14 is suggested to be involved in the formation of a normal-sized autophagosome. The C-terminal half of mammalian Atg14 contains the Barkor/Atg14(L) autophagosome-targeting sequence (BATS) domain that preferentially binds to the highly curved membranes containing PtdIns(3)P and is proposed to target the PtdIns 3-kinase complex efficiently to the isolation membrane. Thus, the Nand C-terminal halves of Atg14 are likely to have an essential core function and a regulatory role, respectively.
Type: article
URI: http://hdl.handle.net/2115/48556
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小原 圭介

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