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Atg14, a key player in orchestrating autophagy
| Title: | Atg14, a key player in orchestrating autophagy |
| Authors: | Obara, Keisuke Browse this author →KAKEN DB | | Ohsumi, Yoshinori Browse this author →KAKEN DB |
| Issue Date: | 13-Oct-2011 |
| Publisher: | Hindawi Publishing |
| Journal Title: | International Journal of Cell Biology |
| Volume: | 2011 |
| Start Page: | 713435 |
| Publisher DOI: | 10.1155/2011/713435 |
| Abstract: | Phosphorylation of phosphatidylinositol (PtdIns) by a PtdIns 3-kinase is an essential process in autophagy. Atg14, a specific subunit of one of the PtdIns 3-kinase complexes, targets the complex to the probable site of autophagosome formation, thereby, sorting the complex to function specifically in autophagy. The N-terminal half of Atg14, containing coiled-coil domains, is required to form the PtdIns 3-kinase complex and target it to the proper site. The C-terminal half of yeast Atg14 is suggested to be involved in the formation of a normal-sized autophagosome. The C-terminal half of mammalian Atg14 contains the Barkor/Atg14(L) autophagosome-targeting sequence (BATS) domain that preferentially binds to the highly curved membranes containing PtdIns(3)P and is proposed to target the PtdIns 3-kinase complex efficiently to the isolation membrane. Thus, the Nand C-terminal halves of Atg14 are likely to have an essential core function and a regulatory role, respectively. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/48556 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 小原 圭介
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