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Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging

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Title: Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging
Authors: Magota, Keiichi Browse this author →KAKEN DB
Kubo, Naoki Browse this author →KAKEN DB
Kuge, Yuji Browse this author →KAKEN DB
Nishijima, Ken-ichi Browse this author
Zhao, Songji Browse this author
Tamaki, Nagara Browse this author →KAKEN DB
Keywords: Integrated PET/SPECT/CT system
Small-animal imaging
Performance measurement
Molecular imaging
Issue Date: Apr-2011
Publisher: Springer Berlin / Heidelberg
Journal Title: European Journal of Nuclear Medicine and Molecular Imaging
Volume: 38
Issue: 4
Start Page: 742
End Page: 752
Publisher DOI: 10.1007/s00259-010-1683-y
PMID: 21153410
Abstract: Purpose: We analyzed the performance of the Inveon for an integrated small-animal PET/SPECT/CT system and compared the imaging capabilities of the SPECT and the PET components. Methods: For SPECT, energy resolution, tomographic spatial resolution, and system sensitivity were evaluated with 99mTc solution using a single pinhole collimator. For PET, spatial resolution, absolute sensitivity, scatter fraction, and peak noise equivalent count (NEC) were evaluated. A micro-Derenzo phantom, cylindrical phantom, and National Electrical Manufacturers Association NU-4 image quality phantom were scanned to compare SPECT and PET image capabilities, and SPECT and PET bone imaging were performed on a normal rat in vivo. Results: SPECT spatial resolution was 0.84 mm full width at half maximum (FWHM) at a radius of rotation of 25 mm using the 0.5-mm pinhole aperture collimator, while PET spatial resolution was 1.63 mm FWHM at the center. SPECT system sensitivity at a radius of rotation of 25 mm was 35.3 cps/MBq (4 × 10^[-3]%) using 0.5-mm pinhole aperture, while PET absolute sensitivity was 3.2% for 350-650 keV and 3.432 ns. Accordingly, the volume sensitivity of PET was three orders of magnitude higher than that of SPECT. Conclusions: This integrated PET/SPECT/CT system provided high system performance with excellent spatial resolution for SPECT and sensitivity for PET. Based on tracer availability and system performance, SPECT and PET have complementary roles for multi-modality small-animal imaging.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 孫田 惠一

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