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Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging
Title: | Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging |
Authors: | Magota, Keiichi Browse this author →KAKEN DB | Kubo, Naoki Browse this author →KAKEN DB | Kuge, Yuji Browse this author →KAKEN DB | Nishijima, Ken-ichi Browse this author | Zhao, Songji Browse this author | Tamaki, Nagara Browse this author →KAKEN DB |
Keywords: | Integrated PET/SPECT/CT system | Small-animal imaging | Performance measurement | Instrumentation | Molecular imaging |
Issue Date: | Apr-2011 |
Publisher: | Springer Berlin / Heidelberg |
Journal Title: | European Journal of Nuclear Medicine and Molecular Imaging |
Volume: | 38 |
Issue: | 4 |
Start Page: | 742 |
End Page: | 752 |
Publisher DOI: | 10.1007/s00259-010-1683-y |
PMID: | 21153410 |
Abstract: | Purpose: We analyzed the performance of the Inveon for an integrated small-animal PET/SPECT/CT system and compared the imaging capabilities of the SPECT and the PET components. Methods: For SPECT, energy resolution, tomographic spatial resolution, and system sensitivity were evaluated with 99mTc solution using a single pinhole collimator. For PET, spatial resolution, absolute sensitivity, scatter fraction, and peak noise equivalent count (NEC) were evaluated. A micro-Derenzo phantom, cylindrical phantom, and National Electrical Manufacturers Association NU-4 image quality phantom were scanned to compare SPECT and PET image capabilities, and SPECT and PET bone imaging were performed on a normal rat in vivo. Results: SPECT spatial resolution was 0.84 mm full width at half maximum (FWHM) at a radius of rotation of 25 mm using the 0.5-mm pinhole aperture collimator, while PET spatial resolution was 1.63 mm FWHM at the center. SPECT system sensitivity at a radius of rotation of 25 mm was 35.3 cps/MBq (4 × 10^[-3]%) using 0.5-mm pinhole aperture, while PET absolute sensitivity was 3.2% for 350-650 keV and 3.432 ns. Accordingly, the volume sensitivity of PET was three orders of magnitude higher than that of SPECT. Conclusions: This integrated PET/SPECT/CT system provided high system performance with excellent spatial resolution for SPECT and sensitivity for PET. Based on tracer availability and system performance, SPECT and PET have complementary roles for multi-modality small-animal imaging. |
Rights: | The original publication is available at www.springerlink.com |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/48719 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 孫田 惠一
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