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Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.
| Title: | Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells. |
| Authors: | Ikeda, Osamu Browse this author | | Mizushima, Akihiro Browse this author | | Sekine, Yuichi Browse this author →KAKEN DB | | Yamamoto, Chikako Browse this author | | Muromoto, Ryuta Browse this author →KAKEN DB | | Nanbo, Asuka Browse this author →KAKEN DB | | Oritani, Kenji Browse this author →KAKEN DB | | Yoshimura, Akihiko Browse this author →KAKEN DB | | Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | Brk | | STAP-2 | | STAT5 | | phosphorylation | | breast cancer |
| Issue Date: | Apr-2011 |
| Publisher: | Wiley |
| Journal Title: | Cancer Science |
| Volume: | 102 |
| Issue: | 4 |
| Start Page: | 756 |
| End Page: | 761 |
| Publisher DOI: | 10.1111/j.1349-7006.2010.01842.x |
| PMID: | 21205088 |
| Abstract: | Signal-transducing adaptor protein (STAP)-2 is a recently identified adaptor protein that contains Pleckstrin homology (PH) and Src homology 2 (SH2)-like domains, and is also known to be a substrate of breast tumor kinase (Brk). In a previous study, we found that STAP-2 upregulated Brk-mediated activation of signal transducer and activator of transcription (STAT) 3 in breast cancer cells. Here, we examined the involvement of STAP-2 in Brk-mediated STAT5 activation in breast cancer cells. Ectopic expression of STAP-2 induced Brk-mediated transcriptional activity of STAT5. Furthermore, STAP-2-knockdown in T47D breast cancer cells induced a marked decrease in proliferation that was as strong as that after Brk- or STAT5b-knockdown. Regarding the mechanism, the PH domain of STAP-2 is likely to participate in the process by which Brk phosphorylates and activates STAT5. Taken together, our findings provide insights toward the development of novel therapeutic strategies as well as novel prognostic values in breast carcinomas. |
| Rights: | The definitive version is available at www.blackwell-synergy.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/48965 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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