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Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.

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Title: Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.
Authors: Ikeda, Osamu Browse this author
Mizushima, Akihiro Browse this author
Sekine, Yuichi Browse this author →KAKEN DB
Yamamoto, Chikako Browse this author
Muromoto, Ryuta Browse this author →KAKEN DB
Nanbo, Asuka Browse this author →KAKEN DB
Oritani, Kenji Browse this author →KAKEN DB
Yoshimura, Akihiko Browse this author →KAKEN DB
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: Brk
breast cancer
Issue Date: Apr-2011
Publisher: Wiley
Journal Title: Cancer Science
Volume: 102
Issue: 4
Start Page: 756
End Page: 761
Publisher DOI: 10.1111/j.1349-7006.2010.01842.x
PMID: 21205088
Abstract: Signal-transducing adaptor protein (STAP)-2 is a recently identified adaptor protein that contains Pleckstrin homology (PH) and Src homology 2 (SH2)-like domains, and is also known to be a substrate of breast tumor kinase (Brk). In a previous study, we found that STAP-2 upregulated Brk-mediated activation of signal transducer and activator of transcription (STAT) 3 in breast cancer cells. Here, we examined the involvement of STAP-2 in Brk-mediated STAT5 activation in breast cancer cells. Ectopic expression of STAP-2 induced Brk-mediated transcriptional activity of STAT5. Furthermore, STAP-2-knockdown in T47D breast cancer cells induced a marked decrease in proliferation that was as strong as that after Brk- or STAT5b-knockdown. Regarding the mechanism, the PH domain of STAP-2 is likely to participate in the process by which Brk phosphorylates and activates STAT5. Taken together, our findings provide insights toward the development of novel therapeutic strategies as well as novel prognostic values in breast carcinomas.
Rights: The definitive version is available at
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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