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Mice lacking Wnt2b are viable and display a postnatal olfactory bulb phenotype

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/49420

Title: Mice lacking Wnt2b are viable and display a postnatal olfactory bulb phenotype
Authors: Tsukiyama, Tadasuke Browse this author →KAKEN DB
Yamaguchi, Terry P. Browse this author
Keywords: Wnt
Embryogenesis
Brain
Redundancy
Olfactory bulb
Issue Date: 14-Mar-2012
Publisher: Elsevier Ireland
Journal Title: Neuroscience Letters
Volume: 512
Issue: 1
Start Page: 48
End Page: 52
Publisher DOI: 10.1016/j.neulet.2012.01.062
Abstract: Wnts are secreted glycoproteins that play important roles in embryonic development. Wnt2b is transiently expressed in the primitive streak (PS) during gastrulation and in several organs during organogenesis. To determine the biological function of Wnt2b during mouse development, we established a conditional null allele of Wnt2b. Mice lacking Wnt2b were viable, fertile, and displayed a normal life span, however, the olfactory bulb in adult Wnt2b mutant mice was significantly reduced in length. Our results suggest that Wnt2b primarily plays a supportive role in gastrulation and organogenesis, functioning redundantly with canonical Wnts, such as Wnt2, in numerous tissues.
Type: article (author version)
URI: http://hdl.handle.net/2115/49420
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 築山 忠維

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