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Mice lacking Wnt2b are viable and display a postnatal olfactory bulb phenotype
Title: | Mice lacking Wnt2b are viable and display a postnatal olfactory bulb phenotype |
Authors: | Tsukiyama, Tadasuke Browse this author →KAKEN DB | Yamaguchi, Terry P. Browse this author |
Keywords: | Wnt | Embryogenesis | Brain | Redundancy | Olfactory bulb |
Issue Date: | 14-Mar-2012 |
Publisher: | Elsevier Ireland |
Journal Title: | Neuroscience Letters |
Volume: | 512 |
Issue: | 1 |
Start Page: | 48 |
End Page: | 52 |
Publisher DOI: | 10.1016/j.neulet.2012.01.062 |
Abstract: | Wnts are secreted glycoproteins that play important roles in embryonic development. Wnt2b is transiently expressed in the primitive streak (PS) during gastrulation and in several organs during organogenesis. To determine the biological function of Wnt2b during mouse development, we established a conditional null allele of Wnt2b. Mice lacking Wnt2b were viable, fertile, and displayed a normal life span, however, the olfactory bulb in adult Wnt2b mutant mice was significantly reduced in length. Our results suggest that Wnt2b primarily plays a supportive role in gastrulation and organogenesis, functioning redundantly with canonical Wnts, such as Wnt2, in numerous tissues. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/49420 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 築山 忠維
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