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効果発現パターンにより抗がん薬を分類するための基礎的検討

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Title: 効果発現パターンにより抗がん薬を分類するための基礎的検討
Other Titles: Basic Investigation for Classification of Anticancer Drugs by Pharmacological Effects
Authors: 高橋, 夏子1 Browse this author
小林, 正紀2 Browse this author →KAKEN DB
板垣, 史郎3 Browse this author
平野, 剛4 Browse this author
武隈, 洋5 Browse this author →KAKEN DB
菅原, 満6 Browse this author →KAKEN DB
井関, 健7 Browse this author →KAKEN DB
Authors(alt): Takahashi, Natsuko1
Kobayashi, Masaki2
Itagaki, Shirou3
Hirano, Takeshi4
Takekuma, Yoh5
Sugawara, Mitsuru6
Iseki, Ken7
Keywords: anticancer drug
concentration-dependent
time-dependent
cell viability
pharmacokinetics/pharmacodynamics
Issue Date: 1-Jun-2012
Publisher: 日本薬学会
Journal Title: Yakugaku Zasshi
Volume: 132
Issue: 6
Start Page: 777
End Page: 783
Publisher DOI: 10.1248/yakushi.132.777
Abstract: The most effective drugs based on the type of cancer are chosen for chemotherapy. Tumor cells can be targeted at the DNA, RNA or protein level, and most of the classical anticancer drugs interact with tumor DNA in a time-dependent manner or a concentration-dependent manner. However, it has been unclear to date whether a combination therapy is carried out by using exact classification. Thus it is necessary to reclassify a great number of anticancer drugs. We propose a new classification system based on pharmacological effects of anticancer drugs. Classification of four anticancer drugs (cisplatin, carboplatin, paclitaxel and gemcitabine) was performed by the 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The four anticancer drugs were grouped by IC50 values (inhibitory concentration, 50%) in a time-dependent manner and a concentration-dependent manner. The present approach may be combined to enhance the chemosensitivity, improve the dose of cytotoxic drugs and evaluate the effects of novel anticancer drugs.
Type: article
URI: http://hdl.handle.net/2115/49553
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小林 正紀

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