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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences >
Peer-reviewed Journal Articles, etc >
Liposomal sn-2 DHA inserted phospholipid decreases tumor size of fibrosarcoma
| Title: | Liposomal sn-2 DHA inserted phospholipid decreases tumor size of fibrosarcoma |
| Authors: | Fujimoto, Akihito Browse this author | | Sasaki, Jin-ichi Browse this author | | Hosokawa, Masashi Browse this author →KAKEN DB | | Takahashi, Koretaro Browse this author →KAKEN DB |
| Keywords: | phospholipid | | liposome | | fibrosarcoma | | phagocytosis | | antitumor |
| Issue Date: | 2002 |
| Publisher: | Japanese Society of Fisheries Science |
| Journal Title: | Fisheries Science |
| Volume: | 68 |
| Issue: | Supplement 2 |
| Start Page: | 1639 |
| End Page: | 1640 |
| Publisher DOI: | 10.2331/fishsci.68.sup2_1639 |
| Abstract: | Liposomes especially the multilamella vesicles (MLV) are known to be phagocyted by macrophages. This was considered to be a problem when designing a drug delivery system. If we take another way of looking at this problem, we could take advantage of this draw back of MLV. For instance, by encapsulating a biological response modifier, we may activate macrophages. The sn-2 docosahexaenoic acid (DHA) inserted phospholipids (2-DHA-PL) have been receiving attentions on their boosting effects on functional compounds such as retinoid or hormones without any serious side effect. For this reason, it is expected to enhance therapeutic effects of the encapsulated compound. In this study, we evaluated the antitumor activity of 2-DHA-PL liposome against Meth-A fibrosarcoma both in vitro and in vivo. |
| Rights: | © 2002 公益社団法人日本水産学会 | | © 2002 The Japanese Society of Fisheries Science |
| Type: | article |
| URI: | http://hdl.handle.net/2115/49564 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 高橋 是太郎
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