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Liposomal sn-2 DHA inserted phospholipid decreases tumor size of fibrosarcoma

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Title: Liposomal sn-2 DHA inserted phospholipid decreases tumor size of fibrosarcoma
Authors: Fujimoto, Akihito Browse this author
Sasaki, Jin-ichi Browse this author
Hosokawa, Masashi Browse this author →KAKEN DB
Takahashi, Koretaro Browse this author →KAKEN DB
Keywords: phospholipid
Issue Date: 2002
Publisher: Japanese Society of Fisheries Science
Journal Title: Fisheries Science
Volume: 68
Issue: Supplement 2
Start Page: 1639
End Page: 1640
Publisher DOI: 10.2331/fishsci.68.sup2_1639
Abstract: Liposomes especially the multilamella vesicles (MLV) are known to be phagocyted by macrophages. This was considered to be a problem when designing a drug delivery system. If we take another way of looking at this problem, we could take advantage of this draw back of MLV. For instance, by encapsulating a biological response modifier, we may activate macrophages. The sn-2 docosahexaenoic acid (DHA) inserted phospholipids (2-DHA-PL) have been receiving attentions on their boosting effects on functional compounds such as retinoid or hormones without any serious side effect. For this reason, it is expected to enhance therapeutic effects of the encapsulated compound. In this study, we evaluated the antitumor activity of 2-DHA-PL liposome against Meth-A fibrosarcoma both in vitro and in vivo.
Rights: © 2002 公益社団法人日本水産学会
© 2002 The Japanese Society of Fisheries Science
Type: article
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋 是太郎

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