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New imidazopyridopyrimidine:naphthyridine base-pairing motif, ImN^[N]:NaO^[O], consisting of a DAAD:ADDA hydrogen bonding pattern, markedly stabilize DNA duplexes

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/49777

Title: New imidazopyridopyrimidine:naphthyridine base-pairing motif, ImN^[N]:NaO^[O], consisting of a DAAD:ADDA hydrogen bonding pattern, markedly stabilize DNA duplexes
Authors: Kuramoto, Kazuyuki Browse this author
Tarashima, Noriko Browse this author
Hirama, Yasuyuki Browse this author
Kikuchi, Yusaku Browse this author
Minakawa, Noriaki Browse this author
Matsuda, Akira Browse this author →KAKEN DB
Issue Date: 14-Oct-2011
Publisher: Royal Society of Chemistry
Journal Title: Chemical Communications
Volume: 47
Issue: 38
Start Page: 10818
End Page: 10820
Publisher DOI: 10.1039/C1CC13805G
PMID: 21863185
Abstract: The new imidazopyridopyrimidine:naphthyridine base-pairing motifs, ImO^[O]:NaN^[N] and ImN^[N]:NaO^[O], were designed. Among the base pairs examined, DNA duplexes containing ImN^[N]:NaO^[O] pair(s) consisting of a DAAD:ADDA hydrogen bonding pattern (D = donor, A = acceptor) were markedly stabilized thermally and thermodynamically.
Rights: Chem. Commun., 2011, 47, 10818-10820 - Reproduced by permission of The Royal Society of Chemistry (RSC)
Type: article (author version)
URI: http://hdl.handle.net/2115/49777
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 彰

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