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A Simulation Study of the Radiation-Induced Bystander Effect : Modeling with Stochastically Defined Signal Reemission
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| Title: | A Simulation Study of the Radiation-Induced Bystander Effect : Modeling with Stochastically Defined Signal Reemission |
| Authors: | Sasaki, Kohei Browse this author | | Wakui, Kosuke Browse this author | | Tsutsumi, Kaori Browse this author →KAKEN DB | | Itoh, Akio Browse this author | | Date, Hiroyuki Browse this author →KAKEN DB |
| Issue Date: | 2012 |
| Publisher: | Hindawi Publishing Corporation |
| Journal Title: | Computational and Mathematical Methods in Medicine |
| Volume: | 2012 |
| Start Page: | 389095 |
| Publisher DOI: | 10.1155/2012/389095 |
| Abstract: | The radiation-induced bystander effect (RIBE) has been experimentally observed for different types of radiation, cell types, and cell culture conditions. However, the behavior of signal transmission between unirradiated and irradiated cells is not well known. In this study, we have developed a new model for RIBE based on the diffusion of soluble factors in cell cultures using a Monte Carlo technique. The model involves the signal emission probability from bystander cells following Poisson statistics. Simulations with this model show that the spatial configuration of the bystander cells agrees well with that of corresponding experiments, where the optimal emission probability is estimated through a large number of simulation runs. It was suggested that the most likely probability falls within 0.63-0.92 for mean number of the emission signals ranging from 1.0 to 2.5. |
| Rights: | http://creativecommons.org/licenses/by/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/51068 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 伊達 広行
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