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Influence of osteon area fraction and degree of orientation of HAp crystals on mechanical properties in bovine femur
| Title: | Influence of osteon area fraction and degree of orientation of HAp crystals on mechanical properties in bovine femur |
| Authors: | Yamada, Satoshi Browse this author →KAKEN DB | | Tadano, Shigeru Browse this author →KAKEN DB | | Fujisaki, Kazuhiro Browse this author →KAKEN DB | | Kodaki, Yuka Browse this author |
| Keywords: | Biomechanics | | Bone | | Osteon | | Hydroxyapatite | | X-ray Diffraction |
| Issue Date: | 4-Jan-2013 |
| Publisher: | Elsevier |
| Journal Title: | Journal of biomechanics |
| Volume: | 46 |
| Issue: | 1 |
| Start Page: | 31 |
| End Page: | 35 |
| Publisher DOI: | 10.1016/j.jbiomech.2012.09.020 |
| PMID: | 23084783 |
| Abstract: | Cortical bone has a hierarchical structure, spanning from the macrostructure at several millimeters or whole bone level, the microstructure at several hundred micrometers level, to the nanostructure at hydroxyapatite (HAp) crystals and collagen fibrils levels. The aim of the study is to understand the relationship between the HAp crystal orientation and the elastic modulus and the relationship between the osteon area fraction and the deformation behavior of HAp crystals in cortical bone. In the experiments, five strip specimens (40×2×1 mm3) aligned with the bone axis were taken from the cortical bone of a bovine femur. The degree of c-axis orientation of HAp crystals in the specimens was measured with the X-ray diffraction technique with the imaging plate. To measure the deformation behavior of HAp crystals in the specimens, tensile tests under X-ray irradiation were conducted. The specimens were cut at the X-ray measurement positions and osteon area fraction and porosity at the transverse cross-sections were observed. Further, the volume fraction of HAp of the specimens was measured. Results showed the degree of c-axis orientation of HAp crystals was positively correlated with the elastic modulus of the specimens (r=0.94). The volume fraction of HAp and the porosity showed no statistical correlation with the elastic modulus and the tensile strength. The HAp crystal strain εH increased linearly with the bone tissue strain ε. The average value of εH/ε was 0.69±0.13 and there was no correlation between the osteon area fraction and εH/ε (r=−0.27, p=0.33). The results suggest that the degree of c-axis orientation of HAp crystals affects the elastic modulus and the magnitude of HAp crystal strain does not depend on the osteon area fraction. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/51137 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 但野 茂
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