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Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice.

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Title: Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice.
Authors: Cui, Hao Browse this author
Hung, Amos C Browse this author
Klaver, David W Browse this author
Suzuki, Toshiharu Browse this author →KAKEN DB
Freeman, Craig Browse this author
Narkowicz, Christian Browse this author
Jacobson, Glenn A Browse this author
Small, David H Browse this author
Issue Date: 2011
Publisher: The Public Library of Science
Journal Title: PloS one
Volume: 6
Issue: 7
Start Page: e23007
Publisher DOI: 10.1371/journal.pone.0023007
PMID: 21829577
Abstract: Alzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP cleaving enzyme (BACE1) and γ-secretase. Enoxaparin, a low molecular weight form of the glycosaminoglycan (GAG) heparin, has been reported to lower Aβ plaque deposition and improve cognitive function in AD transgenic mice.
Rights: http://creativecommons.org/licenses/by/3.0/
Type: article
URI: http://hdl.handle.net/2115/51696
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鈴木 利治

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