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Peer-reviewed Journal Articles, etc >
Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice.
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| Title: | Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice. |
| Authors: | Cui, Hao Browse this author | | Hung, Amos C Browse this author | | Klaver, David W Browse this author | | Suzuki, Toshiharu Browse this author →KAKEN DB | | Freeman, Craig Browse this author | | Narkowicz, Christian Browse this author | | Jacobson, Glenn A Browse this author | | Small, David H Browse this author |
| Issue Date: | 2011 |
| Publisher: | The Public Library of Science |
| Journal Title: | PloS one |
| Volume: | 6 |
| Issue: | 7 |
| Start Page: | e23007 |
| Publisher DOI: | 10.1371/journal.pone.0023007 |
| PMID: | 21829577 |
| Abstract: | Alzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP cleaving enzyme (BACE1) and γ-secretase. Enoxaparin, a low molecular weight form of the glycosaminoglycan (GAG) heparin, has been reported to lower Aβ plaque deposition and improve cognitive function in AD transgenic mice. |
| Rights: | http://creativecommons.org/licenses/by/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/51696 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 鈴木 利治
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