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Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.

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Title: Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.
Authors: Hata, Saori Browse this author →KAKEN DB
Taniguchi, Miyako Browse this author →KAKEN DB
Piao, Yi Browse this author
Ikeuchi, Takeshi Browse this author
Fagan, Anne M Browse this author
Holtzman, David M Browse this author
Bateman, Randall Browse this author
Sohrabi, Hamid R Browse this author
Martins, Ralph N Browse this author
Gandy, Sam Browse this author
Urakami, Katsuya Browse this author →KAKEN DB
Suzuki, Toshiharu Browse this author →KAKEN DB
Issue Date: 2012
Publisher: BioMed Central
Journal Title: Molecular neurodegeneration
Volume: 7
Start Page: 16
Publisher DOI: 10.1186/1750-1326-7-16
PMID: 22534039
Abstract: Alcadeinα (Alcα) is a neuronal membrane protein that colocalizes with the Alzheimer's amyloid-β precursor protein (APP). Successive cleavage of APP by β- and γ-secretases generates the aggregatable amyloid-β peptide (Aβ), while cleavage of APP or Alcα by α- and γ-secretases generates non-aggregatable p3 or p3-Alcα peptides. Aβ and p3-Alcα can be recovered from human cerebrospinal fluid (CSF). We have previously reported alternative processing of APP and Alcα in the CSF of some patients with sporadic mild cognitive impairment (MCI) and AD (SAD).
Rights: http://creativecommons.org/licenses/by/3.0/
Type: article
URI: http://hdl.handle.net/2115/51698
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鈴木 利治

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