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Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1

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Title: Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1
Authors: Miura, Masami Browse this author
Watanabe, Masahiko Browse this author →KAKEN DB
Offermanns, Stefan Browse this author
Simon, Melvin I Browse this author
Kano, Masanobu Browse this author
Issue Date: 1-Oct-2002
Publisher: Society for Neuroscience
Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume: 22
Issue: 19
Start Page: 8379
End Page: 8390
Publisher DOI: 10.1523/JNEUROSCI.22-19-08379.2002
PMID: 12351712
Abstract: For the experiments 39 cats were used. Selective sectioning of either the anterior or the posterior vertical ampullar nerves was performed bilaterally. Additionally in some cats the utricular nerves were cut, or the saccule extirpated on one or both sides. The otolith organs were stimulated by tilting around the bitemporal axis of the animals. Bilateral sectioning of the anterior ampullar nerve induced vertical nystagmus upwards, which disappeared, if the animals were tilted upside down. When the posterior ampullar nerves were cut bilaterally a vertical nystagmus downwards was obtained, and if the animals were tilted upside down there was a large increase in nystagmus frequency. After unilateral extirpation of the saccule, vertical nystagmus downwards was observed in 50 percent of these experiments. This nystagmus was modulated by tilting. However, if the saccules on both sides were extirpated, no nystagmus could be elicited. The cause of these results is discussed.
Relation: http://www.jneurosci.org/content/22/19/8379.full.pdf+html
Type: article
URI: http://hdl.handle.net/2115/51755
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 渡邉 雅彦

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