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Analysis of salivary gland transcripts of the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis

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Title: Analysis of salivary gland transcripts of the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis
Authors: Kato, Hirotomo Browse this author →KAKEN DB
Jochim, Ryan C. Browse this author
Gomez, Eduardo A. Browse this author
Uezato, Hiroshi Browse this author →KAKEN DB
Mimori, Tatsuyuki Browse this author →KAKEN DB
Korenaga, Masataka Browse this author
Sakurai, Tatsuya Browse this author
Katakura, Ken Browse this author →KAKEN DB
Valenzuela, Jesus G. Browse this author
Hashiguchi, Yoshihisa Browse this author →KAKEN DB
Keywords: Lutzomyia ayacuchensis
Salivary gland
cDNA library
Issue Date: Jan-2013
Publisher: Elsevier B.V.
Journal Title: Infection, Genetics and Evolution
Volume: 13
Start Page: 56
End Page: 66
Publisher DOI: 10.1016/j.meegid.2012.08.024
Abstract: The saliva of blood sucking insects contains potent pharmacologically active components that assist them in counteracting the host hemostatic and inflammatory systems during blood feeding. In addition, sand fly salivary proteins affect host immunity and have the potential to be a vaccine against Leishmania infection. In the present study, the salivary gland transcripts of Lutzomyia (Lu.) ayacuchensis, a vector of cutaneous leishmaniasis in Ecuadorian and Peruvian Andes, were analyzed by sequencing randomly selected clones of the salivary gland cDNA library of this sand fly. This resulted in the identification of the most abundant transcripts coding for secreted proteins. These proteins were homologous to the salivary molecules present in other sand flies including the RGD-containing peptide, PpSP15/SL1 family protein, yellow-related protein, putative apyrase, antigen 5-related protein, D7 family protein, and 27 kDa salivary protein. Of note, homologues of maxadilan, an active vasodilator abundantly present in saliva of Lu. longipalpis, were not identified. This analysis is the first description of salivary proteins from a sand fly of the subgenus Helcocyrtomyia and from vector of cutaneous leishmaniasis in the New World. The present analysis will provide further insights into the evolution of salivary components in blood sucking arthropods.
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 大智

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