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Effects of parabens on apoptosis induced by serum-free medium.

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Title: Effects of parabens on apoptosis induced by serum-free medium.
Authors: Egawa, Mari Browse this author
Aoki, Kentaro Browse this author
Sun, Yongkun Browse this author
Hosokawa, Toshiyuki Browse this author →KAKEN DB
Saito, Takeshi Browse this author →KAKEN DB
Kurasaki, Masaaki Browse this author →KAKEN DB
Keywords: PC12 cell
endocrine disrupter
food additives
apoptotic factors
Issue Date: Mar-2012
Publisher: Taylor & Francis
Journal Title: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
Volume: 47
Issue: 3
Start Page: 196
End Page: 204
Publisher DOI: 10.1080/03601234.2012.634341
PMID: 22375591
Abstract: Alkyl esters of p-hydroxybenzoic acids (parabens), an endocrine disrupter, are used as preservatives in cosmetics and foods. In this study, to understand the relationship between parabens and differentiation in infants, the effects of parabens on apoptosis induced by serum deprivation in PC12 cells were investigated. In addition, apoptosis-related factors were assayed. As results, a tendency toward enhancement of apoptosis was observed in the cells cultured in the serum-free medium with methylparaben, and this tendency was suggested to be related to the contents of BAD, a pro-apoptotic protein. Butylparaben did not show any tendency to enhance apoptosis.
Rights: This is an Author's Accepted Manuscript of an article published in Journal of Environmental Science and Health, Part B Pesticides, Food Contaminants, and Agricultural Wastes, Vol. 47, Iss. 3, 2012, copyright Taylor & Francis, available online at:
Type: article (author version)
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藏崎 正明

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