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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Environmental Science / Faculty of Environmental Earth Science >
Peer-reviewed Journal Articles, etc >
Effects of parabens on apoptosis induced by serum-free medium.
| Title: | Effects of parabens on apoptosis induced by serum-free medium. |
| Authors: | Egawa, Mari Browse this author | | Aoki, Kentaro Browse this author | | Sun, Yongkun Browse this author | | Hosokawa, Toshiyuki Browse this author →KAKEN DB | | Saito, Takeshi Browse this author →KAKEN DB | | Kurasaki, Masaaki Browse this author →KAKEN DB |
| Keywords: | PC12 cell | | endocrine disrupter | | food additives | | apoptotic factors | | methylparaben | | butylparaben |
| Issue Date: | Mar-2012 |
| Publisher: | Taylor & Francis |
| Journal Title: | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes |
| Volume: | 47 |
| Issue: | 3 |
| Start Page: | 196 |
| End Page: | 204 |
| Publisher DOI: | 10.1080/03601234.2012.634341 |
| PMID: | 22375591 |
| Abstract: | Alkyl esters of p-hydroxybenzoic acids (parabens), an endocrine disrupter, are used as preservatives in cosmetics and foods. In this study, to understand the relationship between parabens and differentiation in infants, the effects of parabens on apoptosis induced by serum deprivation in PC12 cells were investigated. In addition, apoptosis-related factors were assayed. As results, a tendency toward enhancement of apoptosis was observed in the cells cultured in the serum-free medium with methylparaben, and this tendency was suggested to be related to the contents of BAD, a pro-apoptotic protein. Butylparaben did not show any tendency to enhance apoptosis. |
| Rights: | This is an Author's Accepted Manuscript of an article published in Journal of Environmental Science and Health, Part B Pesticides, Food Contaminants, and Agricultural Wastes, Vol. 47, Iss. 3, 2012, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/03601234.2012.634341. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/52989 |
| Appears in Collections: | 環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 藏崎 正明
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