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Asymmetric Cyanation with the Chiral Ru-Li Combined Catalysts

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Title: Asymmetric Cyanation with the Chiral Ru-Li Combined Catalysts
Authors: Ohkuma, Takeshi Browse this author →KAKEN DB
Kurono, Nobuhito Browse this author
Keywords: aldehydes
asymmetric catalysis
α,β-unsaturated ketones
Issue Date: Aug-2012
Publisher: Georg Thieme Verlag
Journal Title: Synlett
Volume: 23
Issue: 13
Start Page: 1865
End Page: 1881
Publisher DOI: 10.1055/s-0032-1316545
Abstract: The combined systems of phenylglycinate/BINAP/Ru(II) complex and Li compounds have been found to act as highly reactive and enantioselective catalysts for cyanosilylation and hydrocyanation of aldehydes, α-keto esters, α,β-unsaturated ketones, and N-protected aldimines. In this account, we describe the concept of catalyst design, the catalytic efficiency of the novel combined systems in the asymmetric cyanation, and the proposed reaction pathway based on the spectral analysis data. 1 Introduction. 2 Cyanosilylation of Aldehydes and Ketones Catalyzed by LiCl. 3 Asymmetric Cyanosilylation of Aldehydes and α-Keto Esters. 3.1 Design of Chiral Ru-Li Combined Catalyst Systems. 3.2 Cyanosilylation of Aldehydes. 3.3 Cyanosilylation of α-Keto Esters. 4 Asymmetric Hydrocyanation of Aldehydes, α,β-Unsaturated Ketones, and Aldimines. 4.1 Hydrocyanation of Aldehydes. 4.2 Conjugate Cyanation of α,β-Unsaturated Ketones. 4.3 Strecker-Type Reaction. 5 Mechanistic Considerations for Cyanosilylation of Aldehydes and Ketones. 5.1 Achiral Reaction Catalyzed by LiCl. 5.2 Asymmetric Reaction with the Chiral Ru-Li Combined Catalyst. 6 Conclusion.
Rights: © 2012 Georg Thieme Verlag
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大熊 毅

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