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Bone Augmentation Using Novel Unidirectional Porous Hydroxyapatite with Bone Morphogenetic Protein-2 on Rat Skull

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/53343

Title: Bone Augmentation Using Novel Unidirectional Porous Hydroxyapatite with Bone Morphogenetic Protein-2 on Rat Skull
Authors: Kashiwazaki, Haruhiko Browse this author →KAKEN DB
Harada, Naoki Browse this author
Akazawa, Toshiyuki Browse this author →KAKEN DB
Kabir, Md. Arafat Browse this author
Minamida, Yasuhito Browse this author
Murata, Masaru Browse this author →KAKEN DB
Keywords: Unidirectional porous hydroxyapatite (UDPHAp)
Onlay graft
Bone augmentation
Recombinant human bone morphogenetic protein-2 (rhBMP-2)
Issue Date: Jul-2013
Publisher: Journal hard tissue biology
Journal Title: Journal of hard tissue biology
Volume: 22
Issue: 3
Start Page: 337
End Page: 341
Publisher DOI: 10.2485/jhtb.22.337
Abstract: Unidirectional porous hydroxyapatite (UDPHAp) is a material whose microstructure consists of cross-sectional oval pores with a pore diameter in the range of 100-300 mu m that penetrate through the material. UDPHAp has proven suitable for osteogenesis and angiogenesis. The present study was designed to evaluate the osteogenic effect of a newly developed UDPHAp as a carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a rat onlay graft model. UDPHAp was implanted beneath the calvarial periosteum of rats to simulate alveolar bone augmentation in a clinical condition. At 2 weeks after implantation, UDPHAp with rhBMP-2 resulted in active bone formation, and the augmented bone was connected directly with the original bone, whereas commercialized porous hydroxyapatite (PHAp) with rhBMP-2 showed little bone formation. These results suggest that UDPHAp in this model is suitable for onlay graft and is an effective biomaterial for the rhBMP-2 delivery system.
Type: article
URI: http://hdl.handle.net/2115/53343
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 柏崎 晴彦

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