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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Bone Augmentation Using Novel Unidirectional Porous Hydroxyapatite with Bone Morphogenetic Protein-2 on Rat Skull
| Title: | Bone Augmentation Using Novel Unidirectional Porous Hydroxyapatite with Bone Morphogenetic Protein-2 on Rat Skull |
| Authors: | Kashiwazaki, Haruhiko Browse this author →KAKEN DB | | Harada, Naoki Browse this author | | Akazawa, Toshiyuki Browse this author →KAKEN DB | | Kabir, Md. Arafat Browse this author | | Minamida, Yasuhito Browse this author | | Murata, Masaru Browse this author →KAKEN DB |
| Keywords: | Unidirectional porous hydroxyapatite (UDPHAp) | | Onlay graft | | Bone augmentation | | Recombinant human bone morphogenetic protein-2 (rhBMP-2) |
| Issue Date: | Jul-2013 |
| Publisher: | Journal hard tissue biology |
| Journal Title: | Journal of hard tissue biology |
| Volume: | 22 |
| Issue: | 3 |
| Start Page: | 337 |
| End Page: | 341 |
| Publisher DOI: | 10.2485/jhtb.22.337 |
| Abstract: | Unidirectional porous hydroxyapatite (UDPHAp) is a material whose microstructure consists of cross-sectional oval pores with a pore diameter in the range of 100-300 mu m that penetrate through the material. UDPHAp has proven suitable for osteogenesis and angiogenesis. The present study was designed to evaluate the osteogenic effect of a newly developed UDPHAp as a carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a rat onlay graft model. UDPHAp was implanted beneath the calvarial periosteum of rats to simulate alveolar bone augmentation in a clinical condition. At 2 weeks after implantation, UDPHAp with rhBMP-2 resulted in active bone formation, and the augmented bone was connected directly with the original bone, whereas commercialized porous hydroxyapatite (PHAp) with rhBMP-2 showed little bone formation. These results suggest that UDPHAp in this model is suitable for onlay graft and is an effective biomaterial for the rhBMP-2 delivery system. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/53343 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 柏崎 晴彦
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