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Neuroprotective function of DJ-1 in Parkinson's disease.

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/53697

Title: Neuroprotective function of DJ-1 in Parkinson's disease.
Authors: Ariga, Hiroyoshi Browse this author →KAKEN DB
Takahashi-Niki, Kazuko Browse this author →KAKEN DB
Kato, Izumi Browse this author
Maita, Hiroshi Browse this author →KAKEN DB
Niki, Takeshi Browse this author →KAKEN DB
Iguchi-Ariga, Sanae M M Browse this author →KAKEN DB
Issue Date: 2013
Journal Title: Oxidative medicine and cellular longevity
Volume: 2013
Start Page: 683920
Publisher DOI: 10.1155/2013/683920
PMID: 23766857
Abstract: Parkinson's disease (PD) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum. Oxidative stress and mitochondrial dysfunction are thought to be major causes of neurodegeneration in PD. Although genetic and environmental factors are thought to affect the onset of PD, precise mechanisms at the molecular level have not been elucidated. The DJ-1 gene is a causative gene for familial PD (park7) and also an oncogene. DJ-1 has various functions, including transcriptional regulation, antioxidative stress reaction, and chaperone, protease, and mitochondrial regulation, and its activity is regulated by its oxidative status, especially that of cysteine 106 (C106) of DJ-1. Excess oxidation of DJ-1, which renders DJ-1 inactive, has been observed in patients with sporadic PD and Alzheimer's disease, suggesting that DJ-1 also participates in the onset and pathogenesis of sporadic PD as well as familial PD. DJ-1 is also a stress sensor and its expression is increased upon various stresses, including oxidative stress. In this review, we describe functions of DJ-1 against oxidative stress and possible roles of DJ-1 in the pathogenesis of PD.
Type: article
URI: http://hdl.handle.net/2115/53697
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 有賀 寛芳

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