Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >
DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy.
Title: | DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy. |
Authors: | Koide-Yoshida, Shizuyo Browse this author | Niki, Takeshi Browse this author →KAKEN DB | Ueda, Mitsuharu Browse this author →KAKEN DB | Himeno, Shingo Browse this author | Taira, Takahiro Browse this author →KAKEN DB | Iguchi-Ariga, Sanae M M Browse this author →KAKEN DB | Ando, Yukio Browse this author | Ariga, Hiroyoshi Browse this author →KAKEN DB |
Keywords: | DJ-1 | familial amyloidotic polyneuropathy | transthyretin |
Issue Date: | Jun-2007 |
Publisher: | Spandidos Publications |
Journal Title: | International journal of molecular medicine |
Volume: | 19 |
Issue: | 6 |
Start Page: | 885 |
End Page: | 893 |
PMID: | 17487420 |
Abstract: | DJ-1 plays roles in transcriptional regulation and anti-oxidative stress, and loss of its function is thought to result in the onset of Parkinson's disease. DJ-1 has a protease-like structure and transthyretin (TTR), a protein causing familial amyloidotic polyneuropathy (FAP), was identified as a substrate for DJ-1 protease in this study. Both TTR and DJ-1 were secreted into the culture medium under normal conditions, and secreted TTR was not aggregated. Under oxidative conditions, TTR but not DJ-1 was secreted into the culture medium, resulting in aggregation. Mirror images of both the expression patterns and solubility of DJ-1 and TTR were observed in tissues of FAP patients, and an unoxidized form of DJ-1, an inactive form, was secreted into the serum of FAP patients. These results suggest that oxidative stress to cells abrogates secretion of DJ-1 and that secreted DJ-1 degrades aggregated TTR to protect against the onset of FAP. |
Type: | article |
URI: | http://hdl.handle.net/2115/53728 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 有賀 寛芳
|