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Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells.
| Title: | Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells. |
| Authors: | Itoh, Yuka Browse this author →KAKEN DB | | Hayashi, Hidetoshi Browse this author →KAKEN DB | | Xu, Jian Browse this author | | Takii, Takemasa Browse this author →KAKEN DB | | Miyazawa, Keiji Browse this author | | Ariga, Hiroyoshi Browse this author →KAKEN DB | | Akahoshi, Tohru Browse this author →KAKEN DB | | Waguri-Nagaya, Yuko Browse this author | | Otsuka, Takanobu Browse this author →KAKEN DB | | Okamoto, Takashi Browse this author →KAKEN DB | | Onozaki, Kikuo Browse this author →KAKEN DB |
| Keywords: | rheumatoid arthritis | | synoviocytes | | interleukin-1 (IL-1) | | tumor necrosis factor (TNF) α | | androgen | | androgen receptor |
| Issue Date: | Jun-2007 |
| Publisher: | The Pharmaceutical Society of Japan |
| Journal Title: | Biological & pharmaceutical bulletin |
| Volume: | 30 |
| Issue: | 6 |
| Start Page: | 1140 |
| End Page: | 1143 |
| Publisher DOI: | 10.1248/bpb.30.1140 |
| PMID: | 17541168 |
| Abstract: | Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects multiple synovial joints. Proinflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor (TNF)alpha play important roles as principle inflammatory and destructive components of the disease. RA is known to be associated with significant gender differences in its prevalence and clinical features. We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha mRNA expression induced by TNFalpha and the DHT effect was inhibited by an androgen receptor antagonist, hydroxyflutamide (OHF). DHT inhibited the NF-kappaB activation induced by TNFalpha in a manner dependent on the androgen receptor (AR). These results suggest that DHT inhibits the TNFalpha-induced IL-1alpha mRNA expression by inhibiting NF-kappaB activation, and contributes to the gender differences of the disease. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/53729 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 有賀 寛芳
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