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Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells.

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Title: Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells.
Authors: Itoh, Yuka Browse this author →KAKEN DB
Hayashi, Hidetoshi Browse this author →KAKEN DB
Xu, Jian Browse this author
Takii, Takemasa Browse this author →KAKEN DB
Miyazawa, Keiji Browse this author
Ariga, Hiroyoshi Browse this author →KAKEN DB
Akahoshi, Tohru Browse this author →KAKEN DB
Waguri-Nagaya, Yuko Browse this author
Otsuka, Takanobu Browse this author →KAKEN DB
Okamoto, Takashi Browse this author →KAKEN DB
Onozaki, Kikuo Browse this author →KAKEN DB
Keywords: rheumatoid arthritis
synoviocytes
interleukin-1 (IL-1)
tumor necrosis factor (TNF) α
androgen
androgen receptor
Issue Date: Jun-2007
Publisher: The Pharmaceutical Society of Japan
Journal Title: Biological & pharmaceutical bulletin
Volume: 30
Issue: 6
Start Page: 1140
End Page: 1143
Publisher DOI: 10.1248/bpb.30.1140
PMID: 17541168
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects multiple synovial joints. Proinflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor (TNF)alpha play important roles as principle inflammatory and destructive components of the disease. RA is known to be associated with significant gender differences in its prevalence and clinical features. We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha mRNA expression induced by TNFalpha and the DHT effect was inhibited by an androgen receptor antagonist, hydroxyflutamide (OHF). DHT inhibited the NF-kappaB activation induced by TNFalpha in a manner dependent on the androgen receptor (AR). These results suggest that DHT inhibits the TNFalpha-induced IL-1alpha mRNA expression by inhibiting NF-kappaB activation, and contributes to the gender differences of the disease.
Type: article
URI: http://hdl.handle.net/2115/53729
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 有賀 寛芳

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