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DJ-1, a Target Protein for an Endocrine Disrupter, Participates in the Fertilization in Mice

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Title: DJ-1, a Target Protein for an Endocrine Disrupter, Participates in the Fertilization in Mice
Authors: Okada, Masahiko Browse this author
Matsumoto, Ken-ichi Browse this author
Niki, Takeshi Browse this author →KAKEN DB
Taira, Takahiro Browse this author →KAKEN DB
Iguchi-Ariga, Sanae M. M. Browse this author →KAKEN DB
Ariga, Hiroyoshi Browse this author →KAKEN DB
Keywords: DJ-1
endocrine disrupter
Issue Date: Jul-2002
Publisher: The Pharmaceutical Society of Japan
Journal Title: Biological & Pharmaceutical Bulletin
Volume: 25
Issue: 7
Start Page: 853
End Page: 856
Publisher DOI: 10.1248/bpb.25.853
PMID: 12132656
Abstract: DJ-1 was first identified as an activated ras-dependent oncogene product and was later also found to be an infertility-related protein affected by sperm toxicants such as ornidazole (OR) and epichlorohydrin. These findings suggest that DJ-1 has functions in both somatic cells and sperm. In this study, to determine the relationship between DJ-1 and an endocrine disrupter and to determine the functions of DJ-1 in sperm, in vitro fertilization experiments were carried out using eggs and sperm extracted from mice that had or had not been treated with OR. We found that the amount of DJ-1 in sperm and the efficiency of fertilization decreased with the increasing dose of OR to which the mice were exposed. The addition of an anti-mouse DJ-1 serum to sperm solution before the in vitro fertilization reaction with eggs resulted in a decrease in the efficiency of fertilization to about one-third of that when pre-immune serum was added to sperm solution, indicating that DJ-1 participates in the fertilization.
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 有賀 寛芳

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