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Effect of tenascin-X together with vascular endothelial growth factor A on cell proliferation in cultured embryonic hearts.

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Title: Effect of tenascin-X together with vascular endothelial growth factor A on cell proliferation in cultured embryonic hearts.
Authors: Ikuta, Tomoki Browse this author
Ariga, Hiroyoshi Browse this author →KAKEN DB
Matsumoto, Ken-ichi Browse this author
Keywords: tenascin-X
vascular endothelial growth factor A
extracellular matrix
Issue Date: Nov-2001
Publisher: The Pharmaceutical Society of Japan
Journal Title: Biological & pharmaceutical bulletin
Volume: 24
Issue: 11
Start Page: 1320
End Page: 1323
Publisher DOI: 10.1248/bpb.24.1320
PMID: 11725972
Abstract: Tenascin-X (TNX) is a large glycoprotein that appears in extracellular matrices. Previously, we demonstrated that TNX binds to vascular endothelial growth factors A and B (VEGF-A and -B) and that VEGF-B in combination with TNX induces DNA synthesis in endothelial cells via increased signals mediated by the VEGFR-1 receptor. In this study, we investigated the effect of TNX with VEGF-A on the cell proliferation in embryonic mouse heart explants from either wild-type (TNX+/+) or TNX-deficient (TNX-/-) mice. The addition of VEGF-A to the explants from TNX+/+ mice increased cell proliferation by 1.5 fold compared with that in TNX-/- mice, indicating that TNX with VEGF family member plays an important role in the control of endothelial cell proliferation in vivo.
Type: article
URI: http://hdl.handle.net/2115/53745
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 有賀 寛芳

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