|
Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >
Effect of tenascin-X together with vascular endothelial growth factor A on cell proliferation in cultured embryonic hearts.
| Title: | Effect of tenascin-X together with vascular endothelial growth factor A on cell proliferation in cultured embryonic hearts. |
| Authors: | Ikuta, Tomoki Browse this author | | Ariga, Hiroyoshi Browse this author →KAKEN DB | | Matsumoto, Ken-ichi Browse this author |
| Keywords: | tenascin-X | | vascular endothelial growth factor A | | extracellular matrix |
| Issue Date: | Nov-2001 |
| Publisher: | The Pharmaceutical Society of Japan |
| Journal Title: | Biological & pharmaceutical bulletin |
| Volume: | 24 |
| Issue: | 11 |
| Start Page: | 1320 |
| End Page: | 1323 |
| Publisher DOI: | 10.1248/bpb.24.1320 |
| PMID: | 11725972 |
| Abstract: | Tenascin-X (TNX) is a large glycoprotein that appears in extracellular matrices. Previously, we demonstrated that TNX binds to vascular endothelial growth factors A and B (VEGF-A and -B) and that VEGF-B in combination with TNX induces DNA synthesis in endothelial cells via increased signals mediated by the VEGFR-1 receptor. In this study, we investigated the effect of TNX with VEGF-A on the cell proliferation in embryonic mouse heart explants from either wild-type (TNX+/+) or TNX-deficient (TNX-/-) mice. The addition of VEGF-A to the explants from TNX+/+ mice increased cell proliferation by 1.5 fold compared with that in TNX-/- mice, indicating that TNX with VEGF family member plays an important role in the control of endothelial cell proliferation in vivo. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/53745 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 有賀 寛芳
|
