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Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/54030

Title: Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus
Authors: Yoshii, Kentaro Browse this author →KAKEN DB
Moritoh, Kanako Browse this author
Nagata, Noriyo Browse this author →KAKEN DB
Yokozawa, Kana Browse this author
Sakai, Mizuki Browse this author
Sasaki, Nobuya Browse this author →KAKEN DB
Kariwa, Hiroaki Browse this author →KAKEN DB
Agui, Takashi Browse this author →KAKEN DB
Takashima, Ikuo Browse this author →KAKEN DB
Issue Date: May-2013
Publisher: Springer
Journal Title: Archives of Virology
Volume: 158
Issue: 5
Start Page: 1039
End Page: 1046
Publisher DOI: 10.1007/s00705-012-1579-1
PMID: 23266832
Abstract: Tick-borne encephalitis virus (TBEV) is a zoonotic agent that causes fatal encephalitis in humans. 2'-5'-oligoadenylate synthetase 1b (Oas1b) has been identified as a flavivirus resistance gene, but most inbred laboratory mice do not possess a functional Oas1b gene. In this study, a congenic strain carrying a functional Oas1b gene, B6.MSM-Oas, was used to evaluate the pathogenicity of Far-Eastern TBEV. Although intracerebral infection of B6.MSM-Oas mice by Oshima 5-10 resulted in limited signs of illness, infection by Sofjin-HO resulted in death with severe neurologic signs. While Oshima 5-10 was cleared from the brain, Sofjin-HO was not cleared despite a similar level of expression of the intact Oas1b gene. Necrotic neurons with viral antigens and inflammatory reactions were observed in the brain infected with Sofjin-HO. These data indicate that the different susceptibility to the antiviral activity of Oas1b resulted in a difference in neurovirulence in the two TBEV strains.
Type: article (author version)
URI: http://hdl.handle.net/2115/54030
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 好井 健太朗

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