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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus
| Title: | Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus |
| Authors: | Yoshii, Kentaro Browse this author →KAKEN DB | | Moritoh, Kanako Browse this author | | Nagata, Noriyo Browse this author →KAKEN DB | | Yokozawa, Kana Browse this author | | Sakai, Mizuki Browse this author | | Sasaki, Nobuya Browse this author →KAKEN DB | | Kariwa, Hiroaki Browse this author →KAKEN DB | | Agui, Takashi Browse this author →KAKEN DB | | Takashima, Ikuo Browse this author →KAKEN DB |
| Issue Date: | May-2013 |
| Publisher: | Springer |
| Journal Title: | Archives of Virology |
| Volume: | 158 |
| Issue: | 5 |
| Start Page: | 1039 |
| End Page: | 1046 |
| Publisher DOI: | 10.1007/s00705-012-1579-1 |
| PMID: | 23266832 |
| Abstract: | Tick-borne encephalitis virus (TBEV) is a zoonotic agent that causes fatal encephalitis in humans. 2'-5'-oligoadenylate synthetase 1b (Oas1b) has been identified as a flavivirus resistance gene, but most inbred laboratory mice do not possess a functional Oas1b gene. In this study, a congenic strain carrying a functional Oas1b gene, B6.MSM-Oas, was used to evaluate the pathogenicity of Far-Eastern TBEV. Although intracerebral infection of B6.MSM-Oas mice by Oshima 5-10 resulted in limited signs of illness, infection by Sofjin-HO resulted in death with severe neurologic signs. While Oshima 5-10 was cleared from the brain, Sofjin-HO was not cleared despite a similar level of expression of the intact Oas1b gene. Necrotic neurons with viral antigens and inflammatory reactions were observed in the brain infected with Sofjin-HO. These data indicate that the different susceptibility to the antiviral activity of Oas1b resulted in a difference in neurovirulence in the two TBEV strains. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/54030 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 好井 健太朗
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