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Cloned origin of DNA replication in c-myc gene can function and be transmitted in transgenic mice in an episomal state.

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タイトル: Cloned origin of DNA replication in c-myc gene can function and be transmitted in transgenic mice in an episomal state.
著者: Sudo, Katsuko 著作を一覧する
Ogata, Masaaki 著作を一覧する
Sato, Yoshinari 著作を一覧する
Iguchi-Ariga, Sanae M. M. 著作を一覧する
Ariga, Hiroyoshi 著作を一覧する
発行日: 1990年 9月25日
出版者: Oxford University Press
誌名: Nucleic acids research
巻: 18
号: 18
開始ページ: 5425
終了ページ: 5432
出版社 DOI: 10.1093/nar/18.18.5425
抄録: The c-myc protein has recently been shown to interact with a region possessing putative origin of DNA replication and enhancer activities located 2 kb upstream of the c-myc gene itself. Transgenic mice were obtained by injecting constructs containing this region, termed pmyc(H-P), into fertilized mouse eggs. The transgenic elements were capable of efficient replication in all mouse tissues examined and were maintained in an episomal state even in highly differentiated cells. Moreover, pmyc(H-P) was transmittable to the progeny throughout several generations, which suggests that the fragment derived from the region upstream of the c-myc gene possesses sequences necessary for partition, stability and DNA replication of the plasmid in the cells. In addition, we have shown that the plasmid might be captured only by eggs, not by sperm.
Description URI: http://nar.oxfordjournals.org/content/18/18/5425.abstract
資料タイプ: article
URI: http://hdl.handle.net/2115/54048
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 有賀 寛芳

 

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