HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >

Cloned origin of DNA replication in c-myc gene can function and be transmitted in transgenic mice in an episomal state.

Files in This Item:
42_Ariga_1990_Nucleic_Acids_Res.pdf1.9 MBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/54048

Title: Cloned origin of DNA replication in c-myc gene can function and be transmitted in transgenic mice in an episomal state.
Authors: Sudo, Katsuko Browse this author
Ogata, Masaaki Browse this author
Sato, Yoshinari Browse this author
Iguchi-Ariga, Sanae M. M. Browse this author →KAKEN DB
Ariga, Hiroyoshi Browse this author →KAKEN DB
Issue Date: 25-Sep-1990
Publisher: Oxford University Press
Journal Title: Nucleic acids research
Volume: 18
Issue: 18
Start Page: 5425
End Page: 5432
Publisher DOI: 10.1093/nar/18.18.5425
PMID: 02216716
Abstract: The c-myc protein has recently been shown to interact with a region possessing putative origin of DNA replication and enhancer activities located 2 kb upstream of the c-myc gene itself. Transgenic mice were obtained by injecting constructs containing this region, termed pmyc(H-P), into fertilized mouse eggs. The transgenic elements were capable of efficient replication in all mouse tissues examined and were maintained in an episomal state even in highly differentiated cells. Moreover, pmyc(H-P) was transmittable to the progeny throughout several generations, which suggests that the fragment derived from the region upstream of the c-myc gene possesses sequences necessary for partition, stability and DNA replication of the plasmid in the cells. In addition, we have shown that the plasmid might be captured only by eggs, not by sperm.
Description URI: http://nar.oxfordjournals.org/content/18/18/5425.abstract
Type: article
URI: http://hdl.handle.net/2115/54048
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 有賀 寛芳

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 

 - Hokkaido University