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c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.

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この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/54049

タイトル: c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.
著者: Iguchi-Ariga, Sanae M. M. 著作を一覧する
Itani, Teru 著作を一覧する
Yamaguchi, Masamitsu 著作を一覧する
Ariga, Hiroyoshi 著作を一覧する
発行日: 1987年 6月25日
出版者: Oxford University Press
誌名: Nucleic acids research
巻: 15
号: 12
開始ページ: 4889
終了ページ: 4899
出版社 DOI: 10.1093/nar/15.12.4889
抄録: Replicating activity of SV40 origin-containing plasmid was tested in human cells as well as in monkey CosI cells. All the plasmids possessing SV40 ori sequences could replicate, even in the absence of SV40 T antigen, in human HL-60 and Raji cells which are expressing c-myc gene at high level. The copy numbers of the replicated plasmids in these human cells were 1/100 as high as in monkey CosI cells which express SV40 T antigen constitutively. Exactly the same plasmids as the transfected original ones were recovered from the Hirt supernatant of the transfected HL-60 cells. Furthermore, replication of the SV40 ori-containing plasmids in HL-60 cells was inhibited by anti-c-myc antibody co-transfected into the cells. These results indicate that the c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.
Relation (URI): http://nar.oxfordjournals.org/content/15/12/4889.abstract
資料タイプ: article
URI: http://hdl.handle.net/2115/54049
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 有賀 寛芳

 

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