c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.


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27_Ariga_1987_Nucleic_Acids_Res.pdf

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/54049

Title:	c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.
Authors:	Iguchi-Ariga, Sanae M. M. Browse this author →KAKEN DB
	Itani, Teru Browse this author
	Yamaguchi, Masamitsu Browse this author
	Ariga, Hiroyoshi Browse this author →KAKEN DB
Issue Date:	25-Jun-1987
Publisher:	Oxford University Press
Journal Title:	Nucleic acids research
Volume:	15
Issue:	12
Start Page:	4889
End Page:	4899
Publisher DOI:	10.1093/nar/15.12.4889
PMID:	3037484
Abstract:	Replicating activity of SV40 origin-containing plasmid was tested in human cells as well as in monkey CosI cells. All the plasmids possessing SV40 ori sequences could replicate, even in the absence of SV40 T antigen, in human HL-60 and Raji cells which are expressing c-myc gene at high level. The copy numbers of the replicated plasmids in these human cells were 1/100 as high as in monkey CosI cells which express SV40 T antigen constitutively. Exactly the same plasmids as the transfected original ones were recovered from the Hirt supernatant of the transfected HL-60 cells. Furthermore, replication of the SV40 ori-containing plasmids in HL-60 cells was inhibited by anti-c-myc antibody co-transfected into the cells. These results indicate that the c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.
Type:	article
URI:	http://hdl.handle.net/2115/54049
Appears in Collections:	薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 有賀寛芳

OAI-PMH ( junii2 , jpcoar_1.0 )

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