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Milnacipran enhances the control of impulsive action by activating D1-like receptors in the infralimbic cortex

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Title: Milnacipran enhances the control of impulsive action by activating D1-like receptors in the infralimbic cortex
Authors: Tsutsui-Kimura, Iku Browse this author
Ohmura, Yu Browse this author
Izumi, Takeshi Browse this author →KAKEN DB
Kumamoto, Haruko Browse this author
Yamaguchi, Taku Browse this author
Yoshida, Takayuki Browse this author
Yoshioka, Mitsuhiro Browse this author →KAKEN DB
Keywords: Response inhibition
Inhibitory control
Ventromedial prefrontal cortex
Five-choice serial reaction time task
Issue Date: Jan-2013
Publisher: Springer-Verlag
Journal Title: Psychopharmacology
Volume: 225
Issue: 2
Start Page: 495
End Page: 504
Publisher DOI: 10.1007/s00213-012-2835-5
PMID: 22892727
Abstract: Rationale: Elevated impulsivity is often observed in patients with depression. We recently found that milnacipran, an antidepressant and a serotonin/noradrenaline reuptake inhibitor, could enhance impulse control in rats. However, the neural mechanisms underlying the effects of milnacipran on impulsive action remain unclear. Milnacipran increases not only extracellular serotonin and noradrenaline but also dopamine specifically in the medial prefrontal cortex, which is one of brain regions responsible for impulsive action. Objectives: Our goal was to identify whether D1-like and/or D2-like receptors in the infralimbic cortex (IL), the ventral portion of the medial prefrontal cortex, mediates the milnacipran-enhanced impulse control in a three-choice serial reaction time task. Methods: The rats were bilaterally injected with SCH23390, a selective D1-like receptor antagonist (0.3 or 3 ng/side) or eticlopride, a selective D2-like receptor antagonist (0.3 or 1 μg/side) into the IL after acute intraperitoneal administration of milnacipran (10 mg/kg). Results: Intra-IL SCH23390 injections reversed the milnacipran-enhanced impulse control, whereas injections of eticlopride into the IL failed to block the effects of milnacipran on impulsive action. Conclusions: This is the first report that demonstrates a critical role for D1-like receptors of the IL in milnacipran-enhanced control of impulsive action.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大村 優

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