HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
薬学研究院  >
雑誌発表論文等  >

Critical role of cholinergic transmission from the laterodorsal tegmental nucleus to the ventral tegmental area in cocaine-induced place preference

フルテキスト
Text140106v2.pdf704.14 kBPDF見る/開く
この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/54527

タイトル: Critical role of cholinergic transmission from the laterodorsal tegmental nucleus to the ventral tegmental area in cocaine-induced place preference
著者: Shinohara, Fumiya 著作を一覧する
Kihara, Yukari 著作を一覧する
Ide, Soichiro 著作を一覧する
Minami, Masabumi 著作を一覧する
Kaneda, Katsuyuki 著作を一覧する
キーワード: Laterodorsal tegmental nucleus
Ventral tegmental area
Conditioned place preference
Addiction
Acetylcholine
Mesocorticolimbic system
発行日: 2014年 4月
出版者: Elsevier
誌名: Neuropharmacology
巻: 79
開始ページ: 573
終了ページ: 579
出版社 DOI: 10.1016/j.neuropharm.2014.01.019
抄録: Conditioned place preference (CPP) is widely used to investigate the rewarding properties of cocaine. Various brain regions and neurotransmitters are involved in developing cocaine CPP. However, the contribution of cholinergic transmission in the ventral tegmental area (VTA) to cocaine CPP remains largely unexplored. Here, we examined the role of cholinergic input arising from the laterodorsal tegmental nucleus (LDT) to the VTA in the acquisition and expression of cocaine CPP in rats. Intra-LDT injection of carbachol, which hyperpolarizes LDT neurons, and of NMDA and AMPA receptor antagonists before cocaine conditioning blocked and attenuated cocaine CPP, respectively, indicating the necessity of LDT activity for acquiring the CPP. Additionally, intra-VTA injection of scopolamine or mecamylamine before cocaine conditioning also attenuated cocaine CPP, demonstrating the contribution of cholinergic transmission via muscarinic and nicotinic acetylcholine receptors in CPP acquisition. Furthermore, intra-VTA injection of scopolamine or mecamylamine immediately before the test attenuated cocaine CPP, indicating that cholinergic signaling is also associated with the expression of CPP. These results suggest that cholinergic transmission from the LDT to the VTA is critically involved in both acquiring and retrieving cocaine-associated memories in cocaine CPP.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/54527
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 金田 勝幸

 

本サイトに関するご意見・お問い合わせは repo at lib.hokudai.ac.jp へお願いします。 - 北海道大学