|
Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction
| Title: | Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction |
| Authors: | Okamoto, Kazuya Browse this author | | Sakagami, Masahiro Browse this author | | Feng, Fei Browse this author | | Takahashi, Fumiyo Browse this author | | Uotani, Kouichi Browse this author | | Togame, Hiroko Browse this author | | Takemoto, Hiroshi Browse this author | | Ichikawa, Satoshi Browse this author →KAKEN DB | | Matsuda, Akira Browse this author →KAKEN DB |
| Keywords: | Antibacterial | | Ugi-four component reaction | | Natural product | | Nucleoside |
| Issue Date: | 15-Jul-2012 |
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
| Journal Title: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
| Volume: | 22 |
| Issue: | 14 |
| Start Page: | 4810 |
| End Page: | 4815 |
| Publisher DOI: | 10.1016/j.bmcl.2012.05.050 |
| PMID: | 22677318 |
| Abstract: | The second-generation synthesis of 3'-hydroxypacidamycin D (2) has been accomplished via an Ugi-four component reaction at a late stage of the synthesis. This approach provided ready access to a range of analogues including diastereomers of the diaminobutylic acid residue and hybrid-type analogues of mureidomycins. Biological evaluations of these analogues indicated that the stereochemistry at the diaminobutylic acid residue has a crucial impact on both the MraY biochemical inhibition and whole-cell anti-bacterial activity. (C) 2012 Elsevier Ltd. All rights reserved. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/54870 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 松田 彰
|
