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Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction

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Title: Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction
Authors: Okamoto, Kazuya Browse this author
Sakagami, Masahiro Browse this author
Feng, Fei Browse this author
Takahashi, Fumiyo Browse this author
Uotani, Kouichi Browse this author
Togame, Hiroko Browse this author
Takemoto, Hiroshi Browse this author
Ichikawa, Satoshi Browse this author →KAKEN DB
Matsuda, Akira Browse this author →KAKEN DB
Keywords: Antibacterial
Ugi-four component reaction
Natural product
Issue Date: 15-Jul-2012
Volume: 22
Issue: 14
Start Page: 4810
End Page: 4815
Publisher DOI: 10.1016/j.bmcl.2012.05.050
PMID: 22677318
Abstract: The second-generation synthesis of 3'-hydroxypacidamycin D (2) has been accomplished via an Ugi-four component reaction at a late stage of the synthesis. This approach provided ready access to a range of analogues including diastereomers of the diaminobutylic acid residue and hybrid-type analogues of mureidomycins. Biological evaluations of these analogues indicated that the stereochemistry at the diaminobutylic acid residue has a crucial impact on both the MraY biochemical inhibition and whole-cell anti-bacterial activity. (C) 2012 Elsevier Ltd. All rights reserved.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 彰

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