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The DNA-based gels for oral delivery of probiotic bacteria

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Title: The DNA-based gels for oral delivery of probiotic bacteria
Authors: Jonganurakkun, Benjamas1 Browse this author
Nodasaka, Yoshinobu Browse this author
Sakairi, Nobuo Browse this author →KAKEN DB
Nishi, Norio Browse this author
Authors(alt): ジョンアヌラックン, ベンジャマート1
Keywords: biomaterials
probiotic strains
drug delivery system
Issue Date: 5-Jan-2006
Publisher: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Journal Title: Macromolecular Bioscience
Volume: 6
Issue: 1
Start Page: 99
End Page: 103
Publisher DOI: 10.1002/mabi.200500199
PMID: 16374776
Abstract: A single-stranded DNA readily extracted from industrial discarded salmon milt, was used to prepare hydrogels and complex gels by cross-linking with gelatin and κ-carrageenan, for the oral delivery of probiotic bacteria. The complex gels showed a higher protective capability over the hydrogels for approximately one log scale. However, the hydrogels were more stable during 4°C storage. The Lactobacillus and Lactococcus due to protection of the hydrogels could better tolerate to acid than the Bifidobacterium. Furthermore, food-graded hydrogels were prepared and optimized to a similar protective capability for future applications.
Description: Published in Macromolecular Bioscience, 2006, Wiiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Type: article
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: Benjamas Jonganurakkun(ベンジャマート・ジョンアヌラックン)

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