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Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter

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Title: Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter
Authors: Kawamura, Eriko Browse this author
Yamada, Yuma Browse this author →KAKEN DB
Harashima, Hideyoshi Browse this author →KAKEN DB
Keywords: Mitochondria
Mitochondrial drug delivery
Mitochondrial targeting peptide
MITO-Porter
S2 peptide
Nanoparticles
Issue Date: Nov-2013
Publisher: Elsevier sci ltd
Journal Title: Mitochondrion
Volume: 13
Issue: 6
Start Page: 610
End Page: 614
Publisher DOI: 10.1016/j.mito.2013.08.010
PMID: 24012978
Abstract: To achieve mitochondrial therapy, we previously reported on the use of an octaarginine (R8) modified Dual Function (DF)-MITO-Porter for delivering molecules to mitochondria in living cells. In this study, using isolated mitochondria, homogenates and living cells, we evaluated the utility of mitochondrial targeting functional peptides as a ligand for delivering carriers. The S2 peptide modified carrier showed a high mitochondrial targeting activity in homogenates and living cells. In addition, the S2 peptide had a lower cell toxicity compared to R8 modified liposomes. The S2 peptide represents a potentially useful moiety for constructing an efficient and safe mitochondrial delivery system. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Type: article (author version)
URI: http://hdl.handle.net/2115/56636
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 勇磨

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