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Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter
Title: | Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter |
Authors: | Kawamura, Eriko Browse this author | Yamada, Yuma Browse this author →KAKEN DB | Harashima, Hideyoshi Browse this author →KAKEN DB |
Keywords: | Mitochondria | Mitochondrial drug delivery | Mitochondrial targeting peptide | MITO-Porter | S2 peptide | Nanoparticles |
Issue Date: | Nov-2013 |
Publisher: | Elsevier sci ltd |
Journal Title: | Mitochondrion |
Volume: | 13 |
Issue: | 6 |
Start Page: | 610 |
End Page: | 614 |
Publisher DOI: | 10.1016/j.mito.2013.08.010 |
PMID: | 24012978 |
Abstract: | To achieve mitochondrial therapy, we previously reported on the use of an octaarginine (R8) modified Dual Function (DF)-MITO-Porter for delivering molecules to mitochondria in living cells. In this study, using isolated mitochondria, homogenates and living cells, we evaluated the utility of mitochondrial targeting functional peptides as a ligand for delivering carriers. The S2 peptide modified carrier showed a high mitochondrial targeting activity in homogenates and living cells. In addition, the S2 peptide had a lower cell toxicity compared to R8 modified liposomes. The S2 peptide represents a potentially useful moiety for constructing an efficient and safe mitochondrial delivery system. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/56636 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 山田 勇磨
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