|
Hokkaido University Collection of Scholarly and Academic Papers >
Office of Health and Safety >
Peer-reviewed Journal Articles, etc >
Fetal stem cell transplantation : Past, present, and future
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Fetal stem cell transplantation : Past, present, and future |
| Authors: | Ishii, Tetsuya Browse this author |
| Keywords: | Fetal tissue | | Fetal stem cells | | Fetus | | Embryonic stem cells | | Transplantation | | Clinical trials |
| Issue Date: | 26-Sep-2014 |
| Publisher: | Baishideng Publishing Group |
| Journal Title: | World Journal of Stem Cells |
| Volume: | 6 |
| Issue: | 4 |
| Start Page: | 404 |
| End Page: | 420 |
| Publisher DOI: | 10.4252/wjsc.v6.i4.404 |
| Abstract: | Since 1928, human fetal tissues and stem cells have been used worldwide to treat various conditions. Although the transplantation of the fetal midbrain substantia nigra and dopaminergic neurons in patients suffering from Parkinson’s disease is particularly noteworthy, the history of other types of grafts, such as those of the fetal liver, thymus, and pancreas, should be addressed as there are many lessons to be learnt for future stem cell transplantation. This report describes previous practices and complications that led to current clinical trials of isolated fetal stem cells and embryonic stem (ES) cells. Moreover, strategies for transplantation are considered, with a particular focus on donor cells, cell processing, and the therapeutic cell niche, in addition to ethical issues associated with fetal origin. With the advent of autologous induced pluripotent stem cells and ES cells, clinical dependence on fetal transplantation is expected to gradually decline due to lasting ethical controversies, despite landmark achievements. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/56999 |
| Appears in Collections: | 安全衛生本部 (Office of Health and Safety) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 石井 哲也
|
