| Title: | Bone augmentation in rat by highly porous β-TCP scaffolds with different open-cell sizes in combination with fibroblast growth factor-2 |
| Authors: | Miyaji, Hirofumi Browse this author →KAKEN DB |
| Yokoyama, Hiroyuki Browse this author |
| Kosen, Yuta Browse this author |
| Nishimura, Hiroyuki Browse this author |
| Nakane, Kazuyasu Browse this author |
| Tanaka, Saori Browse this author →KAKEN DB |
| Otani, Kaori Browse this author |
| Inoue, Kana Browse this author |
| Ibara, Asako Browse this author |
| Kanayama, Izumi Browse this author |
| Yoshida, Takashi Browse this author |
| Ogawa, Kosuke Browse this author |
| Nishida, Erika Browse this author |
| Kawanami, Masamitsu Browse this author →KAKEN DB |
| Keywords: | bone tissue engineering |
| beta-tricalcium phosphate (β-TCP) |
| regenerative scaffold |
| fibroblast growth factor-2 (FGF2) |
| open-cell structure |
| Issue Date: | 30-Mar-2013 |
| Publisher: | 日本再生歯科医学会 |
| Journal Title: | J Oral Tissue Engin |
| Volume: | 10 |
| Issue: | 3 |
| Start Page: | 172 |
| End Page: | 181 |
| Publisher DOI: | 10.11223/jarde.10.172 |
| Abstract: | We prepared highly porous beta-tricalcium phosphate (β-TCP) scaffolds with different open-cell structure sizes. The aim of this study was to examine whether the open-cell size of the scaffold affected osteoinduction in combination with fibroblast growth factor-2 (FGF2) in rats. Polyurethane foam was immersed in β-TCP slurry and sintered in a furnace. Porous β-TCP scaffolds were prepared in three cell sizes (0.6, 0.4 and 0.3 mm) and characterized. Subsequently, each scaffold with FGF2 was implanted to rat cranial bone. Histomorphometric analyses were taken at 35 days post-surgery. The results showed that each β-TCP scaffold exhibited fully interconnected porosity, and frequently allowed bone tissue ingrowth. The 0.4-mm cell sized scaffold significantly promoted bone augmentation compared to the 0.3-mm type. Resorption of the β-TCP scaffold of 0.4-mm cell size was frequently accelerated. In conclusion, FGF2-loaded β-TCP scaffolds with 0.4-mm cell size would be effective for bone tissue engineering. |
| Rights: | 日本再生歯科医学会(利用は著作権の範囲内に限られます) |
| Type: | article |
| URI: | http://hdl.handle.net/2115/57045 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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