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Bone augmentation in rat by highly porous β-TCP scaffolds with different open-cell sizes in combination with fibroblast growth factor-2

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/57045

Title: Bone augmentation in rat by highly porous β-TCP scaffolds with different open-cell sizes in combination with fibroblast growth factor-2
Authors: Miyaji, Hirofumi Browse this author →KAKEN DB
Yokoyama, Hiroyuki Browse this author
Kosen, Yuta Browse this author
Nishimura, Hiroyuki Browse this author
Nakane, Kazuyasu Browse this author
Tanaka, Saori Browse this author →KAKEN DB
Otani, Kaori Browse this author
Inoue, Kana Browse this author
Ibara, Asako Browse this author
Kanayama, Izumi Browse this author
Yoshida, Takashi Browse this author
Ogawa, Kosuke Browse this author
Nishida, Erika Browse this author
Kawanami, Masamitsu Browse this author →KAKEN DB
Keywords: bone tissue engineering
beta-tricalcium phosphate (β-TCP)
regenerative scaffold
fibroblast growth factor-2 (FGF2)
open-cell structure
Issue Date: 30-Mar-2013
Publisher: 日本再生歯科医学会
Journal Title: J Oral Tissue Engin
Volume: 10
Issue: 3
Start Page: 172
End Page: 181
Publisher DOI: 10.11223/jarde.10.172
Abstract: We prepared highly porous beta-tricalcium phosphate (β-TCP) scaffolds with different open-cell structure sizes. The aim of this study was to examine whether the open-cell size of the scaffold affected osteoinduction in combination with fibroblast growth factor-2 (FGF2) in rats. Polyurethane foam was immersed in β-TCP slurry and sintered in a furnace. Porous β-TCP scaffolds were prepared in three cell sizes (0.6, 0.4 and 0.3 mm) and characterized. Subsequently, each scaffold with FGF2 was implanted to rat cranial bone. Histomorphometric analyses were taken at 35 days post-surgery. The results showed that each β-TCP scaffold exhibited fully interconnected porosity, and frequently allowed bone tissue ingrowth. The 0.4-mm cell sized scaffold significantly promoted bone augmentation compared to the 0.3-mm type. Resorption of the β-TCP scaffold of 0.4-mm cell size was frequently accelerated. In conclusion, FGF2-loaded β-TCP scaffolds with 0.4-mm cell size would be effective for bone tissue engineering.
Rights: 日本再生歯科医学会(利用は著作権の範囲内に限られます)
Type: article
URI: http://hdl.handle.net/2115/57045
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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