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International regulatory landscape and integration of corrective genome editing into in vitro fertilization
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | International regulatory landscape and integration of corrective genome editing into in vitro fertilization |
| Authors: | Araki, Motoko Browse this author | | Ishii, Tetsuya Browse this author |
| Keywords: | Genome editing | | ZFN | | TALEN | | CRISPR/Cas | | Embryonic stem cells | | Zygote | | Embryo | | Assisted reproductive technology | | In vitro fertilization | | Genetic disease | | Prevention | | Germline gene modification | | Regulations |
| Issue Date: | 24-Nov-2014 |
| Publisher: | BioMed Central |
| Journal Title: | Reproductive Biology and Endocrinology |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | 108 |
| Publisher DOI: | 10.1186/1477-7827-12-108 |
| PMID: | 25420886 |
| Abstract: | Genome editing technology, including zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat (CRISPR)/Cas, has enabled far more efficient genetic engineering even in non-human primates. This biotechnology is more likely to develop into medicine for preventing a genetic disease if corrective genome editing is integrated into assisted reproductive technology, represented by in vitro fertilization. Although rapid advances in genome editing are expected to make germline gene correction feasible in a clinical setting, there are many issues that still need to be addressed before this could occur. We herein examine current status of genome editing in mammalian embryonic stem cells and zygotes and discuss potential issues in the international regulatory landscape regarding human germline gene modification. Moreover, we address some ethical and social issues that would be raised when each country considers whether genome editing-mediated germline gene correction for preventive medicine should be permitted. |
| Rights: | http://creativecommons.org/licenses/by/4.0 |
| Type: | article |
| URI: | http://hdl.handle.net/2115/57472 |
| Appears in Collections: | 安全衛生本部 (Office of Health and Safety) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 石井 哲也
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