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Formation of ring-shaped microtubule assemblies through active self-organization on dynein

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Title: Formation of ring-shaped microtubule assemblies through active self-organization on dynein
Authors: Ito, Masaki Browse this author
Kabir, Arif Md. Rashedul Browse this author
Inoue, Daisuke Browse this author
Torisawa, Takayuld Browse this author
Toyoshima, Yoko Browse this author
Sada, Kazuld Browse this author
Kakugo, Akira Browse this author →KAKEN DB
Keywords: active self-organization
ring-shaped assemblies
Issue Date: Apr-2014
Publisher: Nature Publishing Group
Journal Title: Polymer Journal
Volume: 46
Issue: 4
Start Page: 220
End Page: 225
Publisher DOI: 10.1038/pj.2013.89
Abstract: Microtubule (MT)-kinesin, a biomolecular motor system, is a promising candidate for construction of artificial biomachines for a variety of nanotechnology applications. An active self-organization (AcSO) method involving a specific streptavidin (St)-biotin (Bt) interaction has been developed to assemble MTs into a highly ordered structure by exploiting their motility on a kinesincoated surface. Dynein is another biomolecular motor that moves along the MTs in the opposite direction from kinesin. Dynein has not yet been used to demonstrate the AcSO of MTs. In this study, we report the first successful demonstration of the AcSO of MTs on a dynein-coated surface to produce ring-shaped MT assemblies similar to those of kinesin. We found that ring-shaped MT assemblies obtained on dynein showed equal clockwise and counterclockwise rotational motion. This work will enrich the building blocks for designing future oriented motor protein-based artificial devices.
Type: article (author version)
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 角五 彰

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