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Deoxyfluorination of alcohols using N,N-diethyl-α,α-difluoro-(m-methylbenzyl)amine
Title: | Deoxyfluorination of alcohols using N,N-diethyl-α,α-difluoro-(m-methylbenzyl)amine |
Authors: | Kobayashi, Shingo Browse this author | Yoneda, Atushi Browse this author | Fukuhara, Tsuyoshi Browse this author | Hara, Shoji4 Browse this author →KAKEN DB |
Authors(alt): | 原, 正治4 |
Keywords: | Deoxyfluorination | DFMBA | Fluoro sugars | Microwave |
Issue Date: | 2-Aug-2004 |
Publisher: | Elsevier |
Journal Title: | Tetrahedron |
Volume: | 60 |
Issue: | 32 |
Start Page: | 6923 |
End Page: | 6930 |
Publisher DOI: | 10.1016/j.tet.2004.05.089 |
Abstract: | Deoxyfluorination of alcohols was carried out using N,N-diethyl-α,α-difluoro-(m-methylbenzyl)amine (DFMBA). Primary alcohols were effectively converted to fluorides under microwave irradiation or conventional heating. Deoxyfluorination of an anomeric hydroxy group in sugars by DFMBA proceeded at below room temperature and glycosyl fluorides could be obtained in good yields. The deoxyfluorination reaction chemoselectively proceeded and various protecting groups on the sugar can survive under the reaction conditions. |
Relation: | http://www.sciencedirect.com/science/journal/00404020 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/575 |
Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 原 正治
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