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Deoxyfluorination of alcohols using N,N-diethyl-α,α-difluoro-(m-methylbenzyl)amine

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Title: Deoxyfluorination of alcohols using N,N-diethyl-α,α-difluoro-(m-methylbenzyl)amine
Authors: Kobayashi, Shingo Browse this author
Yoneda, Atushi Browse this author
Fukuhara, Tsuyoshi Browse this author
Hara, Shoji4 Browse this author →KAKEN DB
Authors(alt): 原, 正治4
Keywords: Deoxyfluorination
DFMBA
Fluoro sugars
Microwave
Issue Date: 2-Aug-2004
Publisher: Elsevier
Journal Title: Tetrahedron
Volume: 60
Issue: 32
Start Page: 6923
End Page: 6930
Publisher DOI: 10.1016/j.tet.2004.05.089
Abstract: Deoxyfluorination of alcohols was carried out using N,N-diethyl-α,α-difluoro-(m-methylbenzyl)amine (DFMBA). Primary alcohols were effectively converted to fluorides under microwave irradiation or conventional heating. Deoxyfluorination of an anomeric hydroxy group in sugars by DFMBA proceeded at below room temperature and glycosyl fluorides could be obtained in good yields. The deoxyfluorination reaction chemoselectively proceeded and various protecting groups on the sugar can survive under the reaction conditions.
Relation: http://www.sciencedirect.com/science/journal/00404020
Type: article (author version)
URI: http://hdl.handle.net/2115/575
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 原 正治

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