HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >

Mechanism responsible for the antitumor effect of BCG-CWS using the LEEL method in a mouse bladder cancer model

Files in This Item:
WoS_68121_Nakamura.pdf676.5 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: Mechanism responsible for the antitumor effect of BCG-CWS using the LEEL method in a mouse bladder cancer model
Authors: Nakamura, Takashi Browse this author
Fukiage, Masafumi Browse this author
Suzuki, Yoshiteru Browse this author
Yano, Ikuya Browse this author →KAKEN DB
Miyazaki, Jun Browse this author →KAKEN DB
Nishiyama, Hiroyuki Browse this author →KAKEN DB
Akaza, Hideyuki Browse this author →KAKEN DB
Harashima, Hideyoshi Browse this author →KAKEN DB
Keywords: Nanoparticle
Delivery system
Bladder cancer
Cancer immunotherapy
Issue Date: 28-Dec-2014
Publisher: Elsevier
Journal Title: Journal of controlled release
Volume: 196
Start Page: 161
End Page: 167
Publisher DOI: 10.1016/j.jconrel.2014.10.007
PMID: 25315488
Abstract: We previously reported on the development of a water soluble formulation of the cell wall skeleton of BCG (BCG-CWS), a major immune active center of BCG, by encapsulating it into a nanoparticle (CWS-NP). The CWS-NP allowed us to clarify the machinery associated with the BCG mediated anti-bladder tumor effect, especially the roles of bladder cancer cells and dendritic cells (DCs) in the initial step, which remains poorly understood. We show herein that the internalization of BCG-CWS by bladder cancer cells, but not DCs, is indispensable for the induction of an antitumor effect against bladder cancer. Tumor growth was significantly inhibited in mice that had been inoculated with mouse bladder cancer (MBT-2) cells containing internalized BCG-CWS. On the other hand, the internalization of BCG-CWS by DCs had only a minor effect on inducing an antitumor effect against MBT-2 tumors. This was clarified for the first time by using the CWS-NP. This finding provides insights into our understanding of the role of bladder cancer cells and DCs in BCG therapy against bladder cancer. (C) 2014 Elsevier B.V. All rights reserved.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 中村 孝司

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University