HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
薬学研究院  >
雑誌発表論文等  >

Mechanism responsible for the antitumor effect of BCG-CWS using the LEEL method in a mouse bladder cancer model

フルテキスト
WoS_68121_Nakamura.pdf676.5 kBPDF見る/開く
この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/57815

タイトル: Mechanism responsible for the antitumor effect of BCG-CWS using the LEEL method in a mouse bladder cancer model
著者: Nakamura, Takashi 著作を一覧する
Fukiage, Masafumi 著作を一覧する
Suzuki, Yoshiteru 著作を一覧する
Yano, Ikuya 著作を一覧する
Miyazaki, Jun 著作を一覧する
Nishiyama, Hiroyuki 著作を一覧する
Akaza, Hideyuki 著作を一覧する
Harashima, Hideyoshi 著作を一覧する
キーワード: Nanoparticle
Delivery system
Bladder cancer
BCG-CWS
Cancer immunotherapy
発行日: 2014年12月28日
出版者: Elsevier
誌名: Journal of controlled release
巻: 196
開始ページ: 161
終了ページ: 167
出版社 DOI: 10.1016/j.jconrel.2014.10.007
抄録: We previously reported on the development of a water soluble formulation of the cell wall skeleton of BCG (BCG-CWS), a major immune active center of BCG, by encapsulating it into a nanoparticle (CWS-NP). The CWS-NP allowed us to clarify the machinery associated with the BCG mediated anti-bladder tumor effect, especially the roles of bladder cancer cells and dendritic cells (DCs) in the initial step, which remains poorly understood. We show herein that the internalization of BCG-CWS by bladder cancer cells, but not DCs, is indispensable for the induction of an antitumor effect against bladder cancer. Tumor growth was significantly inhibited in mice that had been inoculated with mouse bladder cancer (MBT-2) cells containing internalized BCG-CWS. On the other hand, the internalization of BCG-CWS by DCs had only a minor effect on inducing an antitumor effect against MBT-2 tumors. This was clarified for the first time by using the CWS-NP. This finding provides insights into our understanding of the role of bladder cancer cells and DCs in BCG therapy against bladder cancer. (C) 2014 Elsevier B.V. All rights reserved.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/57815
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 中村 孝司

 

本サイトに関するご意見・お問い合わせは repo at lib.hokudai.ac.jp へお願いします。 - 北海道大学