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Simple prediction of right ventricular ejection fraction using tricuspid annular plane systolic excursion in pulmonary hypertension

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Title: Simple prediction of right ventricular ejection fraction using tricuspid annular plane systolic excursion in pulmonary hypertension
Authors: Sato, Takahiro Browse this author
Tsujino, Ichizo Browse this author →KAKEN DB
Oyama-Manabe, Noriko Browse this author
Ohira, Hiroshi Browse this author
Ito, Yoichi M. Browse this author
Sugimori, Hiroyuki Browse this author
Yamada, Asuka Browse this author
Takashina, Chisa Browse this author
Watanabe, Taku Browse this author
Nishimura, Masaharu Browse this author →KAKEN DB
Keywords: Pulmonary hypertension
Tricuspid annular plane systolic excursion
Cardiac magnetic resonance imaging
Right ventricular ejection fraction
Issue Date: Dec-2013
Publisher: Springer
Journal Title: International journal of cardiovascular imaging
Volume: 29
Issue: 8
Start Page: 1799
End Page: 1805
Publisher DOI: 10.1007/s10554-013-0286-7
PMID: 24002782
Abstract: The present study examined whether tricuspid annular plane systolic excursion (TAPSE) can simply predict right ventricular ejection fraction (RVEF) in patients with pulmonary hypertension (PH). The TAPSE cut-off value to predict reduced RVEF was also evaluated. The association between TAPSE and cardiac magnetic resonance imaging (CMRI)-derived RVEF was examined in 53 PH patients. The accuracy of the prediction equation to calculate RVEF using TAPSE was also evaluated. In PH patients, TAPSE was strongly correlated with CMRI-derived RVEF in PH patients (r = 0.86, p < 0.0001). We then examined the accuracy of the two equations: the original regression equation (RVEF = 2.01 x TAPSE + 0.6) and the simplified prediction equation (RVEF = 2 x TAPSE). Bland-Altman plot showed that the mean difference +/- A limits of agreement was 0.0 +/- A 10.6 for the original equation and -0.6 +/- A 10.6 for the simplified equation. Intraclass correlation coefficient was 0.84 for the original and 0.82 for the simplified equation. Normal RVEF was considered to be a parts per thousand yen40 % based on the data from 53 matched controls, and the best TAPSE cut-off value to determine reduced RVEF (< 40 %) was calculated to be 19.7 mm (sensitivity 88.9 %, specificity 84.6 %). A simple equation of RVEF = 2 x TAPSE enables easy prediction of RVEF using TAPSE, an easily measurable M-mode index of echocardiography. TAPSE of 19.7 mm predicts reduced RVEF in PH patients with clinically acceptable sensitivity and specificity.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 辻野 一三

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