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Problems in methods for the detection of significant proteinuria in pregnancy
| Title: | Problems in methods for the detection of significant proteinuria in pregnancy |
| Authors: | Yamada, Takahiro Browse this author →KAKEN DB | | Kojima, Takashi Browse this author | | Akaishi, Rina Browse this author | | Ishikawa, Satoshi Browse this author | | Takeda, Masamitsu Browse this author | | Kawaguchi, Satoshi Browse this author | | Nishida, Ryutaro Browse this author | | Morikawa, Mamoru Browse this author →KAKEN DB | | Yamada, Takashi Browse this author →KAKEN DB | | Minakami, Hisanori Browse this author →KAKEN DB |
| Keywords: | proteinuria | | creatinine in the urine | | protein to creatinine ratio |
| Issue Date: | Jan-2014 |
| Publisher: | Blackwell Publishing |
| Journal Title: | Journal of Obstetrics and Gynaecology Research |
| Volume: | 40 |
| Issue: | 1 |
| Start Page: | 161 |
| End Page: | 166 |
| Publisher DOI: | 10.1111/jog.12148 |
| PMID: | 24102664 |
| Abstract: | Aim: The aim of this study was to underscore problems associated with the dipstick test and determination of protein concentration alone in spot-urine (P-test) compared with spot-urine protein-to-creatinine ratio (P/Crtest) and to determine whether urine collection for 24-h test was complete. Material and Methods: Dipstick and P/Cr tests were performed simultaneously in 357 random spot-urine specimens from 145 pregnant women, including 35 with pre-eclampsia. Positive results were defined as 1+ on dipstick test, protein concentration 30 mg/dL on P-test, and P/Cr ratio 0.27 (mg/mg) on P/Cr test. Sixty-four 24-h urine tests (quantification of protein in urine collected during 24 h) were performed in 27 of the 145 women. We assumed that P/Cr ratio 0.27 predicted significant proteinuria (urinary protein 0.3 g/day). The 24-h urine collection was considered incomplete when urinary creatinine excretion was <11.0 mg/kg/day or >25.0 mg/kg/day. Results: Forty-four percent (69/156) of specimens with a positive test result on dipstick test contained protein < 30 mg/dL. Dipstick test was positive for 25.7% (69/269) of specimens with protein < 30 mg/dL and for 28.8% (79/274) of specimens with P/Cr ratio < 0.27. P-test results were positive for 7.3% (20/274) and negative for 18.1% (15/83) of specimens with P/Cr ratio < 0.27 and 0.27, respectively. Incomplete 24-h urine collection occurred in 15.6% (10/64) of 24-h urine tests. Daily urinary creatinine excretion was 702–1397 mg, while creatinine concentration varied from 16 mg/dL to 475 mg/dL in spot-urine specimens. Conclusion: Dipstick test and P-test were likely to over- and underestimate risks of significant proteinuria, respectively. The 24-h urine collection was often incomplete. |
| Rights: | The definitive version is available at Wiley Online Library , www.wileyonlinelibrary.com. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/57874 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 水上 尚典
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