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A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis
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| Title: | A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis |
| Authors: | Kon, Shigeyuki Browse this author →KAKEN DB | | Nakayama, Yosuke Browse this author | | Matsumoto, Naoki Browse this author | | Ito, Koyu Browse this author | | Kanayama, Masashi Browse this author | | Kimura, Chiemi Browse this author | | Kouro, Hitomi Browse this author | | Ashitomi, Dai Browse this author | | Matsuda, Tadashi Browse this author →KAKEN DB | | Uede, Toshimitsu Browse this author →KAKEN DB |
| Issue Date: | 29-Dec-2014 |
| Publisher: | Public Library of Science |
| Journal Title: | PLOS one |
| Volume: | 9 |
| Issue: | 12 |
| Start Page: | e116210 |
| Publisher DOI: | 10.1371/journal.pone.0116210 |
| PMID: | 25545242 |
| Abstract: | Osteopontin (OPN) is a multifunctional protein that has been linked to various intractable inflammatory diseases. One way by which OPN induces inflammation is the production of various functional fragments by enzyme cleavage. It has been well appreciated that OPN is cleaved by thrombin, and/or matrix metalloproteinase-3 and -7 (MMP-3/7). Although the function of thrombin-cleaved OPN is well characterized, little is known about the function of MMP-3/7-cleaved OPN. In this study, we found a novel motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved mouse OPN binds to alpha 9b1 integrin. Importantly, this novel motif is involved in the development of anti-type II collagen antibody-induced arthritis (CAIA). This study provides the first in vitro and in vivo evidence that OPN cleavage by MMP-3/7 is an important regulatory mechanism for CAIA. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/57930 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 今 重之
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