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A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/57930

Title: A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis
Authors: Kon, Shigeyuki Browse this author →KAKEN DB
Nakayama, Yosuke Browse this author
Matsumoto, Naoki Browse this author
Ito, Koyu Browse this author
Kanayama, Masashi Browse this author
Kimura, Chiemi Browse this author
Kouro, Hitomi Browse this author
Ashitomi, Dai Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Uede, Toshimitsu Browse this author →KAKEN DB
Issue Date: 29-Dec-2014
Publisher: Public Library of Science
Journal Title: PLOS one
Volume: 9
Issue: 12
Start Page: e116210
Publisher DOI: 10.1371/journal.pone.0116210
PMID: 25545242
Abstract: Osteopontin (OPN) is a multifunctional protein that has been linked to various intractable inflammatory diseases. One way by which OPN induces inflammation is the production of various functional fragments by enzyme cleavage. It has been well appreciated that OPN is cleaved by thrombin, and/or matrix metalloproteinase-3 and -7 (MMP-3/7). Although the function of thrombin-cleaved OPN is well characterized, little is known about the function of MMP-3/7-cleaved OPN. In this study, we found a novel motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved mouse OPN binds to alpha 9b1 integrin. Importantly, this novel motif is involved in the development of anti-type II collagen antibody-induced arthritis (CAIA). This study provides the first in vitro and in vivo evidence that OPN cleavage by MMP-3/7 is an important regulatory mechanism for CAIA.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/57930
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 今 重之

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